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Official Description

Tetanus immune globulin (TIg), human, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90389 refers to Tetanus immune globulin (TIg), which is a human-derived immunizing agent administered via intramuscular injection. This product is a concentrated solution containing antibodies specifically designed to provide short-term, passive immunity against tetanus. Unlike active immunization, where the recipient's immune system is stimulated to produce its own antibodies, the administration of TIg offers immediate protection by supplying pre-formed antibodies directly into the bloodstream. These antibodies are harvested from the pooled blood of multiple donors who have previously developed immunity to tetanus, ensuring a robust source of protection. The use of this code is strictly for reporting the human tetanus immune globulin product itself, emphasizing its role in providing passive immunity rather than stimulating the body's own immune response.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The administration of Tetanus immune globulin (TIg) is indicated in specific clinical scenarios where immediate passive immunity against tetanus is required. The following conditions warrant the use of TIg:

  • Post-exposure prophylaxis for individuals who have sustained a wound that may be contaminated with tetanus spores, particularly in those who are not fully immunized or whose vaccination status is uncertain.
  • Prevention of tetanus in patients who have not received the appropriate tetanus vaccinations, especially in cases of deep puncture wounds or wounds with significant tissue damage.

2. Procedure

The procedure for administering Tetanus immune globulin (TIg) involves several key steps to ensure safe and effective delivery of the immunizing agent. Each step is critical for achieving the desired outcome of passive immunity against tetanus.

  • Step 1: Patient Assessment - Prior to administration, a thorough assessment of the patient's immunization history and current health status is conducted. This includes determining if the patient has had previous tetanus vaccinations and evaluating the nature of the wound, if applicable.
  • Step 2: Preparation of the Product - The TIg solution is prepared for administration. This involves checking the product for any signs of contamination or expiration and ensuring that it is at the appropriate temperature for injection.
  • Step 3: Administration - The TIg is administered via intramuscular injection, typically into the deltoid muscle of the upper arm. The injection site is cleaned with an antiseptic to minimize the risk of infection. Care is taken to inject the solution slowly and steadily to ensure proper absorption.
  • Step 4: Post-Administration Monitoring - After the injection, the patient is monitored for any immediate adverse reactions or side effects. This includes observing for signs of allergic reactions or discomfort at the injection site.

3. Post-Procedure

Following the administration of Tetanus immune globulin (TIg), patients are advised on post-procedure care and monitoring. It is important to inform patients about potential side effects, which may include localized pain, swelling, or redness at the injection site. Patients should be instructed to report any unusual symptoms or allergic reactions, such as difficulty breathing or hives, to their healthcare provider immediately. Additionally, the importance of following up with their primary care provider for any necessary vaccinations or further tetanus prophylaxis should be emphasized to ensure long-term protection against tetanus.

Short Descr TETANUS IG IM
Medium Descr TETANUS IMMUNE GLOBULIN TIG HUMAN IM
Long Descr Tetanus immune globulin (TIg), human, for intramuscular use
Status Code Not Valid for Medicare Purposes
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) P6D - Minor procedures - other (non-Medicare fee schedule)
MUE 0
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
Date
Action
Notes
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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