CPT® Code 80353

The CPT® Code 80353 refers to a laboratory test specifically designed to measure the presence of cocaine in various biological specimens, including meconium stool, urine, serum, or plasma. Cocaine is classified as a highly addictive substance that acts as a central nervous system stimulant and anesthetic, originating from the leaves of the coca plant. This substance functions as a triple reuptake inhibitor (TRI), meaning it influences the brain's neurotransmitter systems by affecting serotonin, norepinephrine, and dopamine receptors. Cocaine can be administered through various routes, including inhalation, injection, or topical absorption. For the purpose of this test, a blood sample is typically obtained through a procedure known as venipuncture, which is separately reportable. Urine samples can be collected either through random voiding or catheterization, while meconium stool is gathered from a diaper. The analysis of serum, plasma, meconium stool, and positive urine screens is conducted using advanced techniques such as quantitative gas chromatography-mass spectrometry and quantitative liquid chromatography-tandem mass spectrometry, ensuring accurate measurement of cocaine levels in the tested specimens.