CPT® Code 80373

The CPT® Code 80373 refers to a laboratory test specifically designed to measure the concentration of tramadol in biological samples such as urine, serum, or plasma. Tramadol, which may be recognized by its brand name Ultram, is classified as a central acting opioid analgesic. Its mechanism of action involves agonizing the opioid receptors in the brain, which helps to alleviate pain by inhibiting the reuptake of neurotransmitters norepinephrine and serotonin. This dual action makes tramadol effective in managing moderate to moderately severe acute or chronic pain, serving as an alternative to traditional opiate medications. Additionally, tramadol can be prescribed in an extended-release formulation for the treatment of fibromyalgia, a condition characterized by widespread musculoskeletal pain. The testing process for tramadol involves obtaining a blood sample through a procedure known as venipuncture, which is reportable separately, or collecting urine via random voiding or catheterization. The analysis of urine, serum, and plasma samples is conducted using a sophisticated technique called quantitative liquid chromatography-tandem mass spectrometry, which allows for precise measurement of tramadol levels in the body.