CPT® Code 80367

The CPT® Code 80367 refers to a laboratory test specifically designed to measure the presence of propoxyphene, also known as dextropropoxyphene, in various biological samples such as meconium stool, urine, serum, or plasma. Propoxyphene is classified as an analgesic and antitussive medication, which was commonly used in combination with other pain relievers like aspirin or acetaminophen. It was marketed under brand names such as Darvon and Darvocet. However, it is important to note that propoxyphene has been removed from the market in the United States since November 2010 due to serious safety concerns, including the risk of fatal overdoses and cardiac arrhythmias associated with its use. The testing process involves obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. For urine samples, collection can be done via random voiding or catheterization, while meconium stool is typically collected from a diaper. The analysis of these samples is conducted using advanced techniques such as quantitative high performance liquid chromatography-tandem mass spectrometry, which allows for precise measurement of the drug levels in the collected specimens.