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The CPT® Code 86765 refers to the laboratory test performed to measure antibodies specific to rubeola, commonly known as measles. This test is crucial for diagnosing current or recent infections as well as for determining immunity status following vaccination. Rubeola is a highly contagious viral infection that spreads through respiratory droplets, leading to symptoms such as fever, runny nose, cough, and a characteristic body rash. The infection can result in serious complications, particularly in vulnerable populations such as infants and children under 5 years of age, as well as adults over 20, who are at a higher risk for severe disease and associated complications like otitis media and pneumonia. The test measures two types of antibodies: IgM and IgG. A positive IgM antibody titer indicates either a current or recent infection or immunization, although it is important to note that low levels of IgM can persist for over 12 months after the initial infection or vaccination. Conversely, a positive IgG antibody titer suggests that the individual has either been exposed to the virus in the past or has been vaccinated. The testing process involves obtaining a blood sample through venipuncture, which is reported separately, and cerebrospinal fluid (CSF) through a lumbar puncture, also reported separately. The laboratory utilizes semi-quantitative enzyme-linked immunosorbent assay (ELISA) for detecting IgM antibodies and semi-quantitative chemiluminescent immunoassay for IgG antibodies, ensuring accurate measurement of the immune response to the rubeola virus.
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