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Official Description

Antibody; Salmonella

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86768 refers to a laboratory test specifically designed to measure antibodies against Salmonella, particularly Salmonella typhi, the bacterium responsible for typhoid fever. Typhoid fever is a serious illness that can be transmitted through fecal contamination, often via contaminated food and water supplies. Individuals infected with S. typhi may not exhibit symptoms but can still carry and shed the bacterium, posing a risk of infection to others. The symptoms associated with typhoid fever include high fever, weakness, abdominal pain, headache, loss of appetite, and a characteristic body rash. The antibody test for Salmonella encompasses various serotypes, including S. typhi H type A, B, D, and O type D and VI. A positive result from this test indicates that the individual has had past exposure to S. paratyphi, either through infection or vaccination. It is important to note that this test is not intended for confirming an acute infection of salmonellosis. The procedure involves obtaining a blood sample through venipuncture, which is reported separately, and the serum is then analyzed using a qualitative immunoblot method to detect the presence of antibodies.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The antibody test for Salmonella, coded as CPT® 86768, is indicated for the following conditions:

  • Typhoid Fever Diagnosis This test is utilized to assess past exposure to Salmonella typhi, which is crucial for diagnosing typhoid fever in individuals who may have been exposed to the bacterium.
  • Assessment of Past Infection The test helps determine if an individual has previously been infected with S. paratyphi, providing valuable information for clinical decision-making.
  • Vaccination Status It can also indicate whether an individual has been vaccinated against typhoid fever, which is important for public health tracking and vaccination programs.

2. Procedure

The procedure for conducting the Salmonella antibody test involves several key steps:

  • Step 1: Patient Preparation Prior to the test, the patient may be advised to avoid certain medications or supplements that could interfere with the results. However, specific preparation instructions should be confirmed with the healthcare provider.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample from the patient. This step is crucial as the blood sample will be used for serum analysis. The site is typically cleaned with an antiseptic to minimize the risk of infection.
  • Step 3: Serum Separation After the blood is drawn, it is allowed to clot, and then the serum is separated from the blood cells. This serum is what will be tested for the presence of Salmonella antibodies.
  • Step 4: Qualitative Immunoblot Testing The separated serum is subjected to qualitative immunoblot testing, which detects specific antibodies against Salmonella typhi. This method allows for the identification of past exposure to the bacterium.
  • Step 5: Result Interpretation Once the testing is complete, the results are interpreted. A positive result indicates past exposure to S. paratyphi, while a negative result suggests no detectable antibodies. It is important to note that this test does not confirm an acute infection of salmonellosis.

3. Post-Procedure

After the procedure, the patient may experience minor discomfort or bruising at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, but patients should be advised to monitor the site for any signs of infection, such as increased redness or swelling. The results of the test will be communicated to the patient by their healthcare provider, who will discuss the implications of the findings and any necessary follow-up actions based on the results.

Short Descr SALMONELLA ANTIBODY
Medium Descr ANTIBODY SALMONELLA
Long Descr Antibody; Salmonella
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 5
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
Date
Action
Notes
1993-01-01 Added First appearance in code book in 1993.
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Description
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