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Official Description

Hemophilus influenza b vaccine (Hib), HbOC conjugate (4 dose schedule), for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90645 refers to the Hemophilus influenza b vaccine (Hib), specifically the HbOC conjugate formulation, which is administered via intramuscular injection. Vaccines, unlike immune globulins that offer short-term, passive immunity, are designed to provide active, long-term immunity. This is achieved by introducing altered versions of specific pathogens, such as viruses or bacteria, into the recipient's body. The immune system responds by producing its own antibodies against these invaders, and it retains the memory of how to produce these antibodies for future encounters with the same antigens. Hemophilus influenza type b (Hib) is particularly concerning for children under the age of five, as it can lead to severe health complications. The bacteria can cause pneumonia, significant swelling of the throat, infections in the joints and bones, and meningitis, which may result in serious outcomes such as brain damage and hearing loss. The code 90645 specifically denotes the HbOC conjugate vaccine that is part of a four-dose schedule, which is crucial for ensuring adequate immunity against Hib. It is important to note that this code solely represents the vaccine product used and does not encompass any additional services or procedures associated with its administration.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Hemophilus influenza b vaccine (Hib) is indicated for the prevention of infections caused by the Hemophilus influenza type b bacteria, particularly in children under the age of five. The following conditions highlight the necessity of this vaccination:

  • Pneumonia - Hib can lead to severe lung infections, resulting in pneumonia, which can be life-threatening in young children.
  • Throat Swelling - The bacteria can cause significant swelling in the throat, potentially obstructing the airway and leading to respiratory distress.
  • Joint and Bone Infections - Hib can infect the joints and bones, leading to painful conditions that may require medical intervention.
  • Meningitis - This serious infection of the protective membranes covering the brain and spinal cord can result in severe complications, including brain damage and deafness.

2. Procedure

The administration of the Hemophilus influenza b vaccine (Hib) using CPT® Code 90645 involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine:

  • Step 1: Preparation - Prior to administration, the healthcare provider must prepare the vaccine according to the manufacturer's instructions. This includes checking the expiration date, ensuring the vaccine is at the appropriate temperature, and shaking the vial gently to mix the contents if necessary.
  • Step 2: Patient Assessment - The healthcare provider should assess the patient’s medical history, including any previous allergic reactions to vaccines, current health status, and any contraindications to vaccination. This step is crucial to ensure the safety and appropriateness of the vaccine for the patient.
  • Step 3: Site Selection - The provider will select an appropriate site for intramuscular injection, typically the anterolateral thigh for infants and young children or the deltoid muscle for older children and adults. The site should be clean and free from any lesions or infections.
  • Step 4: Injection - The vaccine is administered via intramuscular injection using a sterile needle and syringe. The provider will insert the needle at a 90-degree angle to the skin and inject the vaccine slowly to minimize discomfort.
  • Step 5: Post-Administration Care - After the injection, the provider will apply gentle pressure to the injection site with a cotton ball or gauze. The patient will be monitored for a short period for any immediate adverse reactions, and the provider will provide information on potential side effects and aftercare.

3. Post-Procedure

Following the administration of the Hemophilus influenza b vaccine, patients may experience mild side effects such as soreness at the injection site, low-grade fever, or irritability. These reactions are typically short-lived and resolve without intervention. It is important for caregivers to monitor the child for any unusual or severe reactions, such as high fever or signs of an allergic reaction, and to seek medical attention if these occur. The vaccine is part of a four-dose schedule, and it is essential to adhere to the recommended vaccination timeline to ensure optimal immunity against Hib. Documentation of the vaccination, including the date, vaccine lot number, and site of administration, should be recorded in the patient's medical record for future reference and compliance with immunization requirements.

Short Descr HIB VACCINE HBOC IM
Medium Descr HEMOPHILUS INFLUENZA B VACC HBOC CONJ 4 DOSE IM
Long Descr Hemophilus influenza b vaccine (Hib), HbOC conjugate (4 dose schedule), for intramuscular use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE Not applicable/unspecified.
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2016-01-01 Deleted Deleted
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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