© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 90645 refers to the Hemophilus influenza b vaccine (Hib), specifically the HbOC conjugate formulation, which is administered via intramuscular injection. Vaccines, unlike immune globulins that offer short-term, passive immunity, are designed to provide active, long-term immunity. This is achieved by introducing altered versions of specific pathogens, such as viruses or bacteria, into the recipient's body. The immune system responds by producing its own antibodies against these invaders, and it retains the memory of how to produce these antibodies for future encounters with the same antigens. Hemophilus influenza type b (Hib) is particularly concerning for children under the age of five, as it can lead to severe health complications. The bacteria can cause pneumonia, significant swelling of the throat, infections in the joints and bones, and meningitis, which may result in serious outcomes such as brain damage and hearing loss. The code 90645 specifically denotes the HbOC conjugate vaccine that is part of a four-dose schedule, which is crucial for ensuring adequate immunity against Hib. It is important to note that this code solely represents the vaccine product used and does not encompass any additional services or procedures associated with its administration.
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