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Official Description

Diphtheria, tetanus toxoids, and acellular pertussis vaccine and Haemophilus influenzae b vaccine (DTaP/Hib), for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90721 refers to the Diphtheria, tetanus toxoids, and acellular pertussis vaccine combined with the Haemophilus influenzae type b vaccine (DTaP/Hib), intended for intramuscular administration. This vaccine is designed to provide long-lasting immunity against specific bacterial infections by stimulating the body's immune system to produce antibodies. Toxoids, which are inactivated toxins produced by bacteria, play a crucial role in this process by training the immune system to recognize and combat the harmful effects of these toxins. The vaccine exposes the recipient's immune system to altered forms of the bacteria, prompting it to generate its own antibodies. This immunological memory ensures that the body can respond effectively upon subsequent exposures to the same pathogens. The DTaP component of the vaccine is a more refined version of the pertussis vaccine, known as acellular pertussis, which is associated with fewer side effects compared to the whole-cell pertussis vaccine. The combination of these vaccines not only protects against diphtheria and tetanus but also against pertussis and Haemophilus influenzae type b, thereby enhancing overall immunity and public health outcomes.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The DTaP/Hib vaccine (CPT® Code 90721) is indicated for the prevention of several serious bacterial infections. The specific indications include:

  • Diphtheria: A serious bacterial infection affecting the mucous membranes of the throat and nose, which can lead to breathing difficulties, heart failure, and even death.
  • Tetanus: A potentially fatal disease caused by a toxin produced by the bacterium Clostridium tetani, leading to muscle stiffness and spasms.
  • Acellular Pertussis: A highly contagious respiratory disease caused by Bordetella pertussis, characterized by severe coughing fits that can lead to complications, especially in infants.
  • Haemophilus influenzae type b (Hib): A bacterium that can cause severe infections, particularly in young children, including meningitis, pneumonia, and epiglottitis.

2. Procedure

The administration of the DTaP/Hib vaccine involves several key procedural steps:

  • Step 1: Preparation of the vaccine involves ensuring that the vaccine is stored correctly and is at the appropriate temperature for administration. The healthcare provider must check the expiration date and inspect the vial for any particulate matter or discoloration.
  • Step 2: The healthcare provider will select an appropriate site for intramuscular injection, typically the anterolateral thigh for infants and the deltoid muscle for older children and adults. The site is cleaned with an antiseptic wipe to reduce the risk of infection.
  • Step 3: Using a sterile syringe and needle, the provider will draw the correct dosage of the vaccine from the vial. It is essential to expel any air bubbles from the syringe to ensure accurate dosing.
  • Step 4: The needle is then inserted into the muscle at the selected site at a 90-degree angle, and the vaccine is injected slowly and steadily. After the injection, the needle is withdrawn quickly, and gentle pressure is applied to the injection site with a cotton ball or gauze.
  • Step 5: The provider will document the administration of the vaccine in the patient's medical record, including the date, vaccine type, lot number, and the site of administration. This documentation is crucial for tracking immunization history and ensuring compliance with vaccination schedules.

3. Post-Procedure

After the administration of the DTaP/Hib vaccine, patients may experience mild side effects, which are typically self-limiting. Common post-procedure care includes monitoring the patient for any immediate allergic reactions, which may occur within minutes of vaccination. Patients should be advised to observe the injection site for signs of redness, swelling, or tenderness. Over-the-counter pain relievers may be recommended to alleviate any discomfort. It is also important to inform patients or guardians about the expected side effects and when to seek medical attention, particularly if there are signs of a severe allergic reaction or if symptoms persist beyond a few days. Follow-up appointments should be scheduled according to the recommended immunization schedule to ensure complete vaccination coverage.

Short Descr DTAP/HIB VACCINE IM
Medium Descr DTAP/HIB VACCINE FOR INTRAMUSCULAR USE
Long Descr Diphtheria, tetanus toxoids, and acellular pertussis vaccine and Haemophilus influenzae b vaccine (DTaP/Hib), for intramuscular use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE Not applicable/unspecified.
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2016-01-01 Deleted Deleted
2015-07-01 Changed Description Changed
2015-01-01 Changed Description Changed
2014-01-01 Changed Description Changed. Changed Lower Case "t" to Upper Case "T" in the vaccine type DTaP per AMA 2014 corrections document dated 2014-03-24
2011-01-01 Changed Short description changed.
1996-01-01 Added First appearance in code book in 1996.
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