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Official Description

Lyme disease vaccine, adult dosage, for intramuscular use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90665 refers to the Lyme disease vaccine specifically formulated for adult dosage and intended for intramuscular administration. Vaccines, unlike immune globulins, are designed to provide active, long-term immunity. This is achieved by introducing altered versions of specific pathogens, such as viruses or bacteria, into the body. The immune system responds by producing its own antibodies, which are crucial for defending against future infections by the same pathogen. In the case of Lyme disease, the causative agent is the bacterium Borrelia burgdorferi, which is primarily transmitted through the bite of infected ticks. Lyme disease can lead to serious complications if left untreated, potentially affecting the heart, joints, and nervous system. The use of this vaccine is essential in preventing the onset of Lyme disease by equipping the immune system to recognize and combat the bacterium effectively. It is important to note that this code specifically reports the vaccine product used, rather than the administration or any associated services.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Lyme disease vaccine is indicated for adults to prevent Lyme disease, which is caused by the bacterium Borrelia burgdorferi. The vaccine is particularly recommended for individuals who are at higher risk of exposure to infected ticks, such as those living in or traveling to endemic areas where Lyme disease is prevalent.

  • Prevention of Lyme Disease The vaccine is administered to adults to provide immunity against Lyme disease, reducing the risk of infection from tick bites.
  • High-Risk Populations Individuals who engage in outdoor activities in areas known for tick infestations are advised to receive the vaccine to protect against potential exposure.

2. Procedure

The administration of the Lyme disease vaccine involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine.

  • Step 1: Patient Assessment Prior to vaccination, a thorough assessment of the patient’s medical history and potential allergies is conducted to ensure that the vaccine is appropriate for the individual. This includes checking for any contraindications to vaccination.
  • Step 2: Preparation of the Vaccine The vaccine is prepared according to the manufacturer's instructions, which may include shaking the vial to ensure proper suspension and drawing the correct dosage into a syringe. It is crucial to maintain aseptic technique during this process to prevent contamination.
  • Step 3: Administration The vaccine is administered via intramuscular injection, typically in the deltoid muscle of the upper arm. The injection site is cleaned with an antiseptic wipe to minimize the risk of infection. The healthcare provider must ensure that the needle is inserted at the correct angle and depth to deliver the vaccine effectively.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is a standard precaution to ensure patient safety following vaccination.

3. Post-Procedure

Following the administration of the Lyme disease vaccine, patients may experience mild side effects, such as soreness at the injection site, low-grade fever, or fatigue. These symptoms are generally temporary and resolve on their own. Patients are advised to rest and stay hydrated. It is important for individuals to be informed about the potential side effects and to report any unusual or severe reactions to their healthcare provider. Additionally, patients should be educated on the importance of completing the full vaccination series, if applicable, to ensure optimal protection against Lyme disease.

Short Descr LYME DISEASE VACCINE IM
Medium Descr LYME DISEASE VACCINE ADULT IM
Long Descr Lyme disease vaccine, adult dosage, for intramuscular use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Discontinued Code
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE Not applicable/unspecified.
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2013-01-01 Deleted Code deleted
2011-01-01 Changed Medium description changed. Short description changed.
1999-01-01 Added Code added.
Code
Description
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