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Official Description

Cholera vaccine for injectable use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90725 refers to the cholera vaccine specifically designed for injectable use. Vaccines, unlike immune globulins, provide active and long-term immunity by stimulating the recipient's immune system. This is achieved by introducing altered versions of specific viruses or bacteria, which prompts the immune system to produce its own antibodies against these pathogens. Once vaccinated, the body retains a memory of how to produce these antibodies, enabling a quicker and more effective response upon subsequent exposure to the same antigen. The cholera vaccine is particularly important for protection against cholera, an acute diarrheal disease caused by the bacterium Vibrio cholerae. While cholera is not commonly found in industrialized nations, it remains prevalent in regions such as sub-Saharan Africa and the Indian subcontinent. The disease can lead to severe symptoms, including intense diarrhea and vomiting, which may result in cramping, dehydration, and shock, potentially leading to death within hours if not treated promptly. It is important to note that this code specifically reports the vaccine product used for immunization against cholera, rather than any associated services or administration procedures.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The cholera vaccine is indicated for individuals who are at risk of exposure to cholera, particularly those traveling to or residing in areas where the disease is endemic. The following conditions and situations warrant the administration of the cholera vaccine:

  • Travel to Endemic Regions Individuals planning to travel to sub-Saharan Africa or the Indian subcontinent, where cholera outbreaks are more common, should receive the vaccine to reduce their risk of infection.
  • Occupational Exposure Healthcare workers, humanitarian aid workers, and others who may be working in environments with a high risk of cholera transmission are advised to be vaccinated.
  • Outbreak Situations During cholera outbreaks, vaccination may be recommended for individuals in close contact with affected populations to prevent the spread of the disease.

2. Procedure

The administration of the cholera vaccine involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine:

  • Step 1: Patient Assessment Prior to vaccination, a thorough assessment of the patient's medical history and potential allergies is conducted. This includes evaluating any previous reactions to vaccines and determining the appropriateness of the cholera vaccine based on the patient's travel plans or occupational exposure.
  • Step 2: Preparation of the Vaccine The cholera vaccine is prepared according to the manufacturer's instructions. This may involve reconstituting the vaccine if it is in a powdered form or ensuring that the injectable solution is at the correct temperature for administration.
  • Step 3: Administration of the Vaccine The vaccine is administered via an intramuscular or subcutaneous injection, depending on the specific product guidelines. The injection site is typically cleaned with an antiseptic to minimize the risk of infection.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is a standard precaution to ensure patient safety.

3. Post-Procedure

Following the administration of the cholera vaccine, patients are advised to observe for any side effects, which may include mild pain at the injection site, low-grade fever, or fatigue. These symptoms are generally short-lived and resolve without intervention. Patients should be informed about the importance of maintaining hydration and seeking medical attention if they experience severe reactions or symptoms suggestive of an allergic response. Additionally, individuals should be educated on the need for booster doses if required, based on the specific vaccine used and the duration of immunity it provides. It is also essential to remind patients about the importance of practicing good hygiene and sanitation, especially when traveling to areas where cholera is prevalent, to further reduce their risk of infection.

Short Descr CHOLERA VACCINE INJECTABLE
Medium Descr CHOLERA VACCINE INJECTABLE
Long Descr Cholera vaccine for injectable use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE Not applicable/unspecified.
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2016-01-01 Deleted Deleted
2011-01-01 Changed Short description changed.
Pre-1990 Added Code added.
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