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Official Description

Japanese encephalitis virus vaccine, for subcutaneous use

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90735 refers to the Japanese encephalitis virus vaccine, which is administered via subcutaneous injection. Vaccines are designed to provide active, long-term immunity by stimulating the recipient's immune system to recognize and combat specific pathogens. Unlike immune globulins that offer temporary, passive immunity, vaccines work by introducing altered forms of viruses or bacteria, prompting the immune system to produce its own antibodies. This process enables the body to "remember" how to generate these antibodies upon future exposure to the same antigen. The Japanese encephalitis virus vaccine specifically targets the Japanese encephalitis virus, which is transmitted through the bites of infected mosquitoes, particularly those that breed in rice fields. This virus is a significant public health concern in Asia, as it is the leading cause of encephalitis in the region, with mortality rates reaching as high as 60%. The administration of this vaccine is crucial for preventing the disease and its severe complications. It is important to note that this code solely represents the vaccine product itself and does not encompass any associated services or procedures.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Japanese encephalitis virus vaccine is indicated for individuals who are at risk of exposure to the Japanese encephalitis virus, particularly those traveling to or residing in endemic areas. The following conditions and situations warrant the administration of this vaccine:

  • Travel to Endemic Regions Individuals planning to travel to areas where Japanese encephalitis is prevalent, especially during the transmission season, should receive the vaccine to protect against potential infection.
  • Occupational Exposure Persons working in occupations that may expose them to the virus, such as laboratory personnel handling the virus or individuals involved in agricultural activities in endemic regions, are advised to be vaccinated.
  • Residents in Endemic Areas Individuals living in regions where Japanese encephalitis is common may require vaccination to reduce their risk of contracting the disease.

2. Procedure

The administration of the Japanese encephalitis virus vaccine involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine:

  • Step 1: Patient Assessment Prior to vaccination, a thorough assessment of the patient's medical history and potential allergies is conducted. This includes evaluating any previous reactions to vaccines and determining the appropriateness of the Japanese encephalitis vaccine based on the patient's travel plans or occupational exposure.
  • Step 2: Preparation of Vaccine The vaccine is prepared according to the manufacturer's instructions. This includes checking the expiration date, ensuring the vaccine is stored at the correct temperature, and shaking the vial gently to mix the contents if necessary.
  • Step 3: Administration The vaccine is administered subcutaneously, typically in the upper arm or thigh. The injection site is cleaned with an antiseptic wipe to minimize the risk of infection. A sterile syringe and needle are used to draw up the vaccine, and the injection is given at a 45-degree angle to ensure proper delivery into the subcutaneous tissue.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is typically done for about 15 minutes, especially for individuals with a history of allergies or previous vaccine reactions.

3. Post-Procedure

Following the administration of the Japanese encephalitis virus vaccine, patients may experience mild side effects, such as soreness at the injection site, low-grade fever, or fatigue. These symptoms are generally self-limiting and resolve within a few days. Patients are advised to rest and stay hydrated. It is important for individuals to be informed about the signs of more serious adverse reactions, although these are rare. Additionally, patients should be counseled on the importance of completing the vaccination series if multiple doses are required and to follow up with their healthcare provider for any concerns or questions regarding their vaccination status.

Short Descr ENCEPHALITIS VACCINE SC
Medium Descr JAPANESE ENCEPHALITIS VIRUS VACCINE SUBCUTANEOUS
Long Descr Japanese encephalitis virus vaccine, for subcutaneous use
Related Drugs JE-VAX FOR INJECTION
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Nonpass-Through Drugs and Nonimplantable Biologicals, Including Therapeutic Radiopharmaceuticals
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE Not applicable/unspecified.
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
Date
Action
Notes
2016-01-01 Deleted Deleted
2011-01-01 Changed Short description changed.
1994-01-01 Added First appearance in code book in 1994.
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