© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 90630 refers to a specific type of influenza virus vaccine known as the quadrivalent, split virus, preservative-free formulation intended for intradermal use. This vaccine is designed to provide active, long-term immunity against influenza by introducing altered versions of the virus into the recipient's immune system. Unlike immune globulins, which offer short-term, passive immunity, vaccines stimulate the body to produce its own antibodies, enabling it to recognize and combat the virus upon future exposure. The term "preservative-free" indicates that this vaccine does not contain the preservative thimerosal, or contains only trace amounts, and is classified as either thimerosal-free or thimerosal-reduced by the FDA. The administration of this vaccine occurs via intradermal injection, a method that allows for the vaccine to be delivered into the skin rather than into the muscle. The production of this influenza vaccine involves the use of embryonated chicken eggs, where the virus is cultivated, harvested, and inactivated using formaldehyde. The process includes concentrating and purifying the virus, followed by chemical disruption to create a split virus, which is then further purified. The quadrivalent formulation is specifically designed to protect against four distinct influenza viruses, comprising two strains of influenza type A and two strains of influenza type B, thereby enhancing the vaccine's effectiveness in providing comprehensive protection against circulating influenza strains.
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