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Official Description

Amikacin

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80150 refers to the laboratory test for measuring Amikacin levels in the blood. Amikacin is classified as an injectable aminoglycoside antibiotic, primarily utilized in the treatment of severe or serious systemic bacterial infections caused by gram-negative organisms. The measurement of Amikacin levels is critical due to the drug's potential side effects, which include auditory and vestibular toxicity, renal toxicity, and the risk of neuromuscular blockade, which can lead to paralysis of muscles, including those essential for respiration. Monitoring blood levels of Amikacin is essential to ensure therapeutic efficacy while minimizing the risk of adverse effects. The test can be performed at random times or specifically at peak or trough levels, which are defined by specific timing relative to the administration of the drug. A random sample can be collected at any time, while peak levels are typically drawn 15 to 30 minutes after the completion of an intravenous infusion or 90 minutes after an intramuscular injection. Trough levels, on the other hand, are collected 30 minutes prior to the next dose of the drug. The blood sample for this test is obtained through a venipuncture, which is a separately reportable procedure. The serum from the blood sample is then analyzed using a fluorescence polarization immunoassay, a method that allows for accurate quantification of Amikacin levels in the bloodstream.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Amikacin blood test (CPT® Code 80150) is indicated for the following conditions:

  • Severe Gram-Negative Infections - The test is performed to monitor Amikacin levels in patients being treated for serious systemic bacterial infections caused by gram-negative bacteria.
  • Assessment of Drug Toxicity - Monitoring is necessary due to the potential for Amikacin to cause auditory, vestibular, and renal toxicity, as well as neuromuscular blockade.
  • Therapeutic Drug Monitoring - The test is used to ensure that Amikacin levels remain within a therapeutic range to maximize efficacy while minimizing the risk of adverse effects.

2. Procedure

The procedure for measuring Amikacin levels involves several key steps:

  • Sample Collection - A blood sample is obtained through venipuncture, which is a procedure where a needle is inserted into a vein to draw blood. This step is crucial as it provides the serum needed for testing.
  • Timing of Sample Draw - The timing of the blood sample collection is critical. For peak levels, the sample is drawn 15 to 30 minutes after the completion of an intravenous infusion or 90 minutes after an intramuscular injection. For trough levels, the sample is collected 30 minutes prior to the next scheduled dose of Amikacin. Random samples can be drawn at any time during the treatment.
  • Laboratory Analysis - Once the blood sample is collected, the serum is tested using a fluorescence polarization immunoassay. This analytical method allows for the precise measurement of Amikacin concentrations in the blood, ensuring accurate monitoring of the drug's levels.

3. Post-Procedure

After the blood sample has been collected and sent for analysis, there are no specific post-procedure care instructions required for the patient. However, it is essential to monitor the patient for any signs of toxicity related to Amikacin, especially if the drug is being administered concurrently. The results of the Amikacin level test will guide further treatment decisions, including dosage adjustments if necessary, to ensure the safety and effectiveness of the therapy.

Short Descr ASSAY OF AMIKACIN
Medium Descr DRUG SCREEN QUANTITATIVE AMIKACIN
Long Descr Amikacin
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
Date
Action
Notes
2013-01-01 Changed Medium description changed per AMA 2013 corrections document dated January 25, 2013.
1993-01-01 Added First appearance in code book in 1993.
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