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Official Description

Lithium

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80178 refers to a laboratory test specifically designed to measure the levels of lithium in the blood. Lithium, commonly known by its brand names such as Eskalith or Lithobid, is a medication that functions as a neurotransmitter, playing a crucial role in regulating the flow of sodium through nerve and muscle cells. This regulation is particularly important in the management of bipolar disorder, where lithium is utilized to stabilize the manic phase of the condition. Additionally, lithium may be prescribed for other medical issues, including cluster headaches and bipolar depression. Due to its narrow therapeutic range, it is essential to monitor lithium blood levels closely, especially during the initial stages of therapy when the dosage is being adjusted. Blood samples for lithium testing should ideally be drawn 12 hours after the last dose to ensure accurate measurement. The blood sample is collected through a venipuncture, which is a procedure that can be reported separately. Once collected, the serum is analyzed using a method known as reflectance spectrophotometry, which allows for precise quantification of lithium levels in the bloodstream.

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