CPT® Code 80197

The CPT® Code 80197 refers to a laboratory test specifically designed to measure the levels of tacrolimus in the blood. Tacrolimus, commonly known by its brand name Prograf, is an immunosuppressant medication that plays a critical role in preventing organ rejection in transplant patients. It works by inhibiting the activity of certain white blood cells, which are essential for the immune response against transplanted organs such as the kidney, liver, heart, and lung. The administration of tacrolimus is typically done intravenously, either as a standalone treatment or in conjunction with other immunosuppressive agents to enhance its effectiveness. Due to its narrow therapeutic range, careful monitoring of tacrolimus levels is essential to ensure that patients receive the appropriate dosage. Initially, blood levels may be assessed daily when starting therapy, then tapering to 1-2 times per week, and eventually to once every 1-2 months for routine monitoring. The blood specimen for this test is collected as a trough level, which means it is taken just before the next scheduled dose and at least 12 hours after the last dose. The testing process involves obtaining a blood sample through a separately reportable venipuncture, followed by analysis using liquid chromatography-tandem mass spectrometry. It is important to note that tacrolimus can also be tested using chromatographic or immunoassay techniques, which may yield slightly different results; therefore, the specific technique used should be documented when comparing current results with previous levels.