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Official Description

Caffeine

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80155 refers to a laboratory test specifically designed to measure the levels of caffeine in the blood. Caffeine, classified as a methylxanthine, is a central nervous system stimulant that plays a significant role in respiratory stimulation. This test is particularly relevant in the context of treating apnea in premature infants, where maintaining appropriate caffeine levels is crucial for effective management. The procedure involves drawing random blood samples, which are essential for establishing and monitoring therapeutic levels of caffeine in the patient's system. Blood samples can be obtained through methods such as venipuncture or heel stick, depending on the patient's age and condition. The analysis of the serum or plasma is conducted using a quantitative enzyme multiplied immunoassay technique, which provides precise measurements of caffeine concentration, aiding healthcare providers in making informed treatment decisions.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The caffeine blood test (CPT® Code 80155) is indicated for the following conditions:

  • Apnea in Premature Infants This test is performed to monitor caffeine levels in premature infants who are being treated for apnea, a condition characterized by pauses in breathing.

2. Procedure

The procedure for conducting the caffeine blood test involves several key steps to ensure accurate measurement of caffeine levels in the blood.

  • Step 1: Sample Collection A blood sample is obtained from the patient, which can be done through venipuncture or heel stick. The choice of method depends on the patient's age and clinical condition. For infants, heel stick is often preferred due to its less invasive nature.
  • Step 2: Sample Handling Once the blood sample is collected, it is important to handle it properly to prevent contamination or degradation. The sample should be processed promptly to ensure the integrity of the caffeine measurement.
  • Step 3: Laboratory Analysis The serum or plasma obtained from the blood sample is then subjected to testing using the quantitative enzyme multiplied immunoassay technique. This method allows for precise quantification of caffeine levels, providing essential data for therapeutic monitoring.

3. Post-Procedure

After the caffeine blood test is completed, healthcare providers will review the results to determine if the caffeine levels are within the therapeutic range. If the levels are too low, adjustments to the caffeine dosage may be necessary. Conversely, if levels are too high, it may indicate a need for dosage reduction. Continuous monitoring may be required to ensure that the patient maintains appropriate caffeine levels, especially in the context of ongoing treatment for apnea in premature infants. Additionally, healthcare providers should provide guidance on any necessary follow-up tests or evaluations based on the results of the caffeine test.

Short Descr DRUG ASSAY CAFFEINE
Medium Descr DRUG ASSAY CAFFEINE
Long Descr Caffeine
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2014-01-01 Added Added
Code
Description
Code
Description
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