CPT® Code 80195

The CPT® Code 80195 refers to a laboratory test specifically designed to measure the levels of sirolimus in the blood. Sirolimus, also known by its brand name Rapamune, is classified as an immunosuppressant medication. It plays a crucial role in preventing the body’s immune system from rejecting transplanted organs, such as kidneys, livers, and hearts. The administration of sirolimus can occur either as a standalone treatment or in conjunction with other immunosuppressive agents to enhance its effectiveness. Due to its narrow therapeutic range, careful monitoring of sirolimus levels is essential to ensure that the drug remains within a safe and effective concentration in the bloodstream. Initially, blood levels may be assessed daily when starting therapy, then tapering to 1-2 times per week, and eventually to once every 1-2 months for ongoing management. For routine monitoring, blood specimens are collected as trough levels, which means the sample is taken immediately before the next scheduled dose and at least 12 hours after the previous dose. The blood sample is obtained through a venipuncture, which is a separately reportable procedure. The testing of sirolimus levels is performed using advanced techniques such as liquid chromatography-tandem mass spectrometry, although it may also be analyzed using chromatographic or immunoassay methods, which can yield slightly different results.