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Official Description

Tobramycin

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 80200 refers to the measurement of tobramycin levels in the blood. Tobramycin is classified as an injectable aminoglycoside antibiotic that is primarily utilized in the treatment of severe or serious bacterial infections. The measurement of tobramycin levels is critical due to the drug's potential side effects, which include auditory, vestibular, and renal toxicity. Monitoring these levels helps ensure that the drug is administered safely and effectively. The testing can be performed at various times, including random, peak, and trough levels. A random sample can be collected at any time, while peak and trough levels are specifically time-dependent. Typically, trough levels are drawn 5 to 90 minutes before the administration of the drug, either through intravenous infusion or intramuscular injection. Conversely, peak levels are collected 30 minutes after the completion of an intravenous infusion or 30 to 90 minutes following an intramuscular injection. The blood sample required for this test is obtained through a venipuncture, which is a separately reportable procedure. The analysis of the blood serum is conducted using a method known as fluorescence polarization immunoassay, which allows for accurate measurement of the tobramycin concentration in the bloodstream.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The measurement of tobramycin levels is indicated in the following scenarios:

  • Severe or Serious Bacterial Infections The primary indication for tobramycin testing is its use in treating severe or serious bacterial infections, where monitoring is essential to ensure therapeutic effectiveness and safety.
  • Risk of Toxicity Due to the potential for auditory, vestibular, and renal toxicity associated with tobramycin, monitoring blood levels is crucial to prevent adverse effects.
  • Therapeutic Drug Monitoring Regular monitoring is necessary to maintain appropriate drug levels, particularly in patients receiving intravenous or intramuscular injections of tobramycin.

2. Procedure

The procedure for measuring tobramycin levels involves several key steps:

  • Sample Collection A blood sample is obtained through a venipuncture, which is a procedure where a needle is inserted into a vein to draw blood. This step is critical as it provides the serum needed for testing tobramycin levels.
  • Timing of Sample Draw The timing of the blood sample collection is essential for accurate measurement. A random sample can be drawn at any time, while trough levels must be collected 5 to 90 minutes before the administration of the drug. Peak levels are drawn 30 minutes after the intravenous infusion is completed or 30 to 90 minutes after an intramuscular injection.
  • Laboratory Testing Once the blood sample is collected, the serum is tested using fluorescence polarization immunoassay. This laboratory technique allows for the precise quantification of tobramycin levels in the blood, ensuring that the results are reliable for clinical decision-making.

3. Post-Procedure

After the blood sample has been collected and sent for analysis, there are no specific post-procedure care requirements for the patient related to the blood draw itself. However, it is important for healthcare providers to monitor the patient for any signs of toxicity associated with tobramycin, especially if the levels are found to be outside the therapeutic range. The results of the tobramycin level tests will guide further treatment decisions, including dosage adjustments or the need for additional monitoring. Regular follow-up may be necessary, particularly in patients receiving ongoing therapy with tobramycin, to ensure continued safety and efficacy of the treatment.

Short Descr ASSAY OF TOBRAMYCIN
Medium Descr DRUG SCREEN QUANTITATIVE TOBRAMYCIN
Long Descr Tobramycin
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GW Service not related to the hospice patient's terminal condition
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
Action
Notes
2013-01-01 Changed Medium description changed per AMA 2013 corrections document dated January 25, 2013.
1993-01-01 Added First appearance in code book in 1993.
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