CPT® Code 88388

Deleted

Macroscopic examination, dissection, and preparation of tissue for non-microscopic analytical studies (eg, nucleic acid-based molecular studies); in conjunction with a touch imprint, intraoperative consultation, or frozen section, each tissue preparation (eg, a single lymph node) (List separately in addition to code for primary procedure)

The CPT® Code 88388 refers to the macroscopic examination, dissection, and preparation of tissue specifically for non-microscopic analytical studies, such as nucleic acid-based molecular studies. This procedure involves a thorough visual examination of the tissue sample, where definitive characteristics are noted to assess the sample's quality and relevance. Following this examination, the tissue undergoes dissection, which allows for a more detailed evaluation of its structure and composition. The preparation of the tissue is a critical step, which may involve fixing the tissue using chemical agents like aldehydes or alcohols, or alternatively, freezing the tissue to preserve its integrity for further analysis. Once prepared, the tissue is embedded in a medium such as paraffin or resin, which facilitates the slicing of the tissue into thin sections. These sections are essential for conducting non-microscopic analytical studies, particularly those that focus on nucleic acids. Such molecular studies are crucial for diagnosing various conditions, including genetic disorders and malignant neoplasms, as they help identify specific genetic mutations associated with these diseases. After the completion of the analytical studies, the physician interprets the results and compiles a written report detailing the findings. It is important to note that CPT® Code 88388 is used when the tissue preparation is performed in conjunction with other procedures, such as a touch imprint, intraoperative consultation, or frozen section, and should be listed separately in addition to the code for the primary procedure.