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Code deleted, see 80353, 80361, 86160-86162

Official Description

Cocaine or metabolite

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82520 refers to a laboratory test specifically designed to detect and quantify the presence of cocaine or its metabolites in various biological specimens, including blood, urine, or meconium. This test is critical in clinical settings, particularly in emergency situations where there is a suspicion of cocaine ingestion or overdose. The procedure involves obtaining a blood sample through venipuncture, which is a method of drawing blood from a vein, or collecting a random urine sample. In the case of newborns, meconium, which is the first stool passed by an infant, may be tested to assess exposure to cocaine. The analysis is performed using quantitative gas chromatography-mass spectrometry, a sophisticated technique that allows for precise measurement of the drug's concentration in the specimen. This testing is essential for guiding clinical decisions and ensuring appropriate medical intervention in cases of suspected drug use.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The test coded as CPT® 82520 is indicated in specific clinical scenarios where the presence of cocaine or its metabolites needs to be confirmed. The following conditions warrant the performance of this test:

  • Suspected Cocaine Ingestion The test is performed when there is a clinical suspicion of cocaine use, particularly in emergency situations where rapid diagnosis is crucial.
  • Overdose Situations In cases of suspected overdose, this test helps in determining the presence and quantity of cocaine, which is vital for appropriate medical management.
  • Newborn Testing For newborns, testing may be indicated to assess exposure to cocaine through meconium analysis, which can provide insights into maternal drug use during pregnancy.

2. Procedure

The procedure for conducting the test associated with CPT® 82520 involves several key steps to ensure accurate results. Each step is critical for the integrity of the testing process:

  • Step 1: Sample Collection The first step involves obtaining the appropriate biological specimen. For adults, a blood sample is collected through venipuncture, which is the process of inserting a needle into a vein to draw blood. For urine testing, a random urine sample is collected from the patient. In the case of newborns, meconium is collected, which is the first stool passed by the infant, to test for drug exposure.
  • Step 2: Sample Preparation Once the specimen is collected, it is prepared for analysis. This may involve processing the blood sample to separate serum or plasma, depending on the testing requirements. The urine or meconium samples are also prepared according to laboratory protocols to ensure they are suitable for testing.
  • Step 3: Testing Methodology The prepared samples are then subjected to quantitative gas chromatography-mass spectrometry (GC-MS). This advanced analytical technique allows for the separation and quantification of cocaine and its metabolites in the specimen. The use of GC-MS is essential for providing accurate and reliable results, which are crucial for clinical decision-making.

3. Post-Procedure

After the completion of the testing procedure associated with CPT® 82520, the laboratory will analyze the results and report the findings. Clinicians will receive a detailed report indicating the presence and concentration of cocaine or its metabolites in the tested specimen. It is important for healthcare providers to interpret these results in the context of the patient's clinical presentation and history. Follow-up care may be necessary based on the test results, especially in cases of confirmed cocaine use or overdose, where immediate medical intervention may be required. Additionally, proper documentation of the test results and any subsequent actions taken is essential for compliance and continuity of care.

Short Descr ASSAY OF COCAINE
Medium Descr COCAINE/METABOLITE
Long Descr Cocaine or metabolite
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2015-01-01 Deleted Code deleted, see 80353, 80361, 86160-86162
Pre-1990 Added Code added.
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Description
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