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CPT®
82666

CPT® Code 82666
Deleted

Code deleted, see 80327, 80328

Official Description

Epiandrosterone

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82666 refers to a laboratory test specifically designed to measure the level of epiandrosterone in the body. Epiandrosterone is a steroid that is naturally produced from the adrenal hormone dehydroepiandrosterone (DHEA). This compound is of interest in medical testing due to its weak androgenic activity, which means it has a limited ability to promote male characteristics. Additionally, epiandrosterone may play a role as an anti-estrogenic agent, potentially contributing to the reduction of inflammation in certain breast cancer cells. Understanding the levels of epiandrosterone can provide valuable insights into hormonal balance and may assist in the evaluation of specific medical conditions related to hormone regulation and breast cancer treatment.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The laboratory test for epiandrosterone is indicated for various clinical scenarios where hormonal evaluation is necessary. The following conditions may warrant the measurement of epiandrosterone levels:

  • Hormonal Imbalance Assessment of patients presenting with symptoms of hormonal imbalance, which may include changes in mood, energy levels, or sexual function.
  • Adrenal Function Evaluation Evaluation of adrenal gland function, particularly in cases of suspected adrenal insufficiency or hyperplasia.
  • Breast Cancer Monitoring Monitoring of patients with breast cancer, especially in relation to the anti-estrogenic properties of epiandrosterone and its potential impact on inflammation in cancer cells.

2. Procedure

The procedure for measuring epiandrosterone levels involves several key steps that ensure accurate and reliable results. The following outlines the procedural steps:

  • Step 1: Sample Collection A blood sample is collected from the patient, typically via venipuncture. This step is crucial as it provides the necessary biological material for testing. Proper collection techniques must be followed to avoid contamination and ensure the integrity of the sample.
  • Step 2: Sample Preparation Once the blood sample is collected, it is processed in the laboratory. This may involve centrifugation to separate the serum or plasma from the cellular components of the blood. The preparation of the sample is essential for accurate measurement of epiandrosterone levels.
  • Step 3: Laboratory Analysis The prepared sample is then subjected to specific laboratory techniques, such as immunoassays or chromatography, to quantify the concentration of epiandrosterone. These methods are designed to provide precise measurements and are validated for clinical use.
  • Step 4: Result Interpretation After the analysis is complete, the results are interpreted by qualified laboratory personnel. The findings are then reported to the requesting physician, who will consider the results in the context of the patient's clinical picture.

3. Post-Procedure

Post-procedure care for patients undergoing the epiandrosterone test is generally minimal, as the test is non-invasive and does not require any specific recovery time. Patients may resume their normal activities immediately following the blood draw. However, it is important for healthcare providers to communicate the expected timeline for receiving test results, which can vary based on laboratory processing times. Additionally, any abnormal results should be discussed with the patient to determine the next steps in evaluation or treatment, if necessary.
Short Descr ASSAY OF EPIANDROSTERONE
Medium Descr ASSAY OF EPIANDROSTERONE
Long Descr Epiandrosterone
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2015-01-01 Deleted Code deleted, see 80327, 80328
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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