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Code deleted, see 80324, 80325, 80326

Official Description

Amphetamine or methamphetamine

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82145 refers to laboratory testing specifically for the presence of amphetamine or methamphetamine in biological samples. These substances are classified as psychostimulant drugs belonging to the phenethylamine class, which are known for their stimulating effects on the central nervous system. The testing can be conducted on various types of specimens, including urine, blood, or meconium stool, particularly in newborn infants. Amphetamines and methamphetamines are often associated with recreational use and are sometimes misused for enhancing athletic performance. However, they also have legitimate medical applications, as they may be prescribed to manage symptoms in individuals diagnosed with Attention Deficit Disorder (ADD) and Attention Deficit Hyperactivity Disorder (ADHD). The laboratory analysis typically involves obtaining a sample from the patient, which is then subjected to a sophisticated testing method known as quantitative liquid chromatography-tandem mass spectrometry. This method allows for precise measurement and identification of the substances in the sample, ensuring accurate results for clinical or forensic purposes.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The laboratory testing for amphetamine or methamphetamine is indicated in various clinical scenarios, particularly when there is a suspicion of substance use or abuse. The following conditions may warrant such testing:

  • Substance Abuse Evaluation Testing may be performed to assess potential abuse of amphetamines or methamphetamines, especially in individuals presenting with behavioral changes or signs of intoxication.
  • Monitoring Treatment Patients undergoing treatment for Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD) may be tested to ensure compliance with prescribed medication regimens.
  • Newborn Screening In cases where there is a concern for maternal substance use during pregnancy, testing of meconium stool in newborns can help identify exposure to amphetamines or methamphetamines.

2. Procedure

The procedure for testing amphetamine or methamphetamine involves several key steps to ensure accurate and reliable results. The following outlines the procedural steps involved:

  • Sample Collection A biological sample is collected from the patient, which may include urine, blood, or meconium stool. The choice of sample type depends on the clinical context and the specific indications for testing.
  • Sample Preparation Once collected, the sample undergoes preparation to isolate the substances of interest. This may involve processes such as centrifugation for blood samples or specific handling techniques for urine and meconium stool samples.
  • Testing Methodology The prepared sample is then analyzed using quantitative liquid chromatography-tandem mass spectrometry. This advanced testing method allows for the precise quantification and identification of amphetamine and methamphetamine in the sample.
  • Result Interpretation After the analysis, the results are interpreted by qualified laboratory personnel. The findings are then documented and reported, providing essential information for clinical decision-making.

3. Post-Procedure

Post-procedure care primarily involves the interpretation of test results and any necessary follow-up actions based on those results. If the test indicates the presence of amphetamines or methamphetamines, further evaluation may be required to assess the implications for the patient's health or treatment plan. In cases of newborn screening, appropriate interventions may be initiated to address any identified issues related to maternal substance use. Additionally, healthcare providers may need to discuss the results with the patient or their guardians, providing guidance on the next steps, which may include counseling, further testing, or adjustments to treatment plans.

Short Descr ASSAY OF AMPHETAMINES
Medium Descr AMPHETAMINE/METHAMPHETAMINE
Long Descr Amphetamine or methamphetamine
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 9 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE Not applicable/unspecified.
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2015-01-01 Deleted Code deleted, see 80324, 80325, 80326
Pre-1990 Added Code added.
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Description
Code
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