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Official Description

Antibody; adenovirus

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86603 refers to the laboratory test for antibodies to adenovirus. This test involves analyzing a blood sample to detect the presence of antibodies, which are proteins produced by the immune system in response to an infection. Adenoviruses are a group of viruses that can lead to various illnesses, primarily affecting the respiratory system. Common symptoms associated with adenovirus infections include upper respiratory infections, which may manifest as the common cold, pneumonia, croup, and bronchitis. Additionally, adenoviruses can cause gastroenteritis, conjunctivitis, cystitis, and skin rashes. In some cases, these viruses can lead to acute respiratory disease (ARD). The testing for adenovirus antibodies is typically conducted using enzyme-linked immunosorbent assay (ELISA) methodology, a sensitive and specific technique for detecting antibodies in the blood. The test can measure two types of immunoglobulins: IgG and IgM. IgG testing is utilized to determine if there has been a past or current infection, while IgM testing is specifically aimed at identifying a current infection with a particular adenovirus strain. It is important to note that if both IgG and IgM tests are performed, each test should be reported separately to ensure accurate coding and billing.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The antibody test for adenovirus (CPT® Code 86603) is indicated for the following conditions:

  • Upper Respiratory Infections Symptoms may include cough, sore throat, and nasal congestion, which are commonly associated with adenovirus infections.
  • Pneumonia Adenoviruses can lead to pneumonia, particularly in young children and immunocompromised individuals.
  • Croup This condition, characterized by a distinctive barking cough, can be caused by adenovirus infections.
  • Bronchitis Inflammation of the bronchial tubes can occur due to adenovirus, leading to coughing and difficulty breathing.
  • Gastroenteritis Adenoviruses can also cause inflammation of the stomach and intestines, resulting in diarrhea and vomiting.
  • Conjunctivitis Adenovirus is a common cause of viral conjunctivitis, leading to redness and irritation of the eyes.
  • Cystitis Inflammation of the bladder can occur due to adenovirus infection.
  • Rash Some adenovirus infections may present with skin rashes.
  • Acute Respiratory Disease (ARD) This serious condition can result from adenovirus infections, particularly in vulnerable populations.

2. Procedure

The procedure for testing antibodies to adenovirus involves several key steps:

  • Step 1: Sample Collection A blood sample is collected from the patient, typically via venipuncture. This sample serves as the basis for the antibody testing.
  • Step 2: Laboratory Processing The collected blood sample is sent to a laboratory where it undergoes processing. This may involve separating the serum from the blood cells to prepare it for testing.
  • Step 3: Antibody Testing The laboratory performs the antibody test using enzyme-linked immunosorbent assay (ELISA) methodology. This technique allows for the detection of specific antibodies (IgG and IgM) against adenovirus in the serum.
  • Step 4: Result Interpretation After the testing is completed, the laboratory interprets the results. A positive IgM result indicates a current infection, while a positive IgG result suggests a past or current infection.
  • Step 5: Reporting The results are documented and reported to the healthcare provider. If both IgG and IgM tests were performed, each result is reported separately to ensure accurate coding and billing.

3. Post-Procedure

Post-procedure care for patients undergoing adenovirus antibody testing is generally minimal, as the blood draw is a routine procedure. Patients may be advised to drink plenty of fluids and to monitor the site of the blood draw for any signs of infection or excessive bruising. Results from the antibody test can take several days to process, and patients should follow up with their healthcare provider to discuss the findings and any necessary next steps based on the results. It is important for healthcare providers to consider the clinical context when interpreting the results, as the presence of antibodies does not always correlate with active disease.

Short Descr ADENOVIRUS ANTIBODY
Medium Descr ANTIBODY ADENOVIRUS
Long Descr Antibody; adenovirus
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
2021-01-01 Changed First appearance of guideline addition in code book.
2020-04-10 Changed AMA Guideline added
1993-01-01 Added First appearance in code book in 1993.
Code
Description
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