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Official Description

Antibody; herpes simplex, type 2

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86696 refers to the laboratory test for antibodies specific to herpes simplex virus type 2 (HSV-2). This test is performed on a sample of blood or cerebrospinal fluid to detect the presence of antibodies that indicate an immune response to HSV-2 infection. Herpes simplex virus is primarily transmitted through direct contact with an infected individual, and the initial infection often manifests as ulcerations on the skin or mucous membranes. After the primary infection, the virus can enter a dormant state within the body and may reactivate due to various triggers, including other illnesses, infections, or stress. Certain populations, such as neonates and individuals with compromised immune systems, are particularly vulnerable to severe complications, including ocular or central nervous system infections. Various testing methodologies are available for diagnosing HSV infections, including indirect hemagglutination (IHA), chemiluminescent immunoassay, and enzyme-linked immunosorbent assay (ELISA). The testing typically involves measuring immunoglobulin G (IgG) and immunoglobulin M (IgM) levels to confirm the presence of HSV infection. It is important to report each immunoglobulin class separately if both IgG and IgM tests are conducted. For non-specific HSV testing, the code 86694 is utilized, while code 86695 is designated for tests specific to HSV type 1. Code 86696 is specifically reserved for tests that identify antibodies related to HSV type 2, including glycoprotein G-specific antibody IgG and/or IgM testing.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The antibody test for herpes simplex virus type 2 (HSV-2) is indicated for several clinical scenarios, including:

  • Diagnosis of HSV-2 Infection The test is performed to confirm the presence of antibodies in individuals suspected of having an HSV-2 infection based on clinical symptoms or exposure history.
  • Assessment of Immune Response The test helps evaluate the immune response in patients who have been previously infected with HSV-2, particularly in those experiencing recurrent symptoms.
  • Screening in High-Risk Populations Individuals in high-risk groups, such as sexually active adults or those with multiple sexual partners, may be screened for HSV-2 antibodies to identify asymptomatic infections.
  • Monitoring Immunocompromised Patients The test is crucial for monitoring patients with weakened immune systems, such as those with HIV/AIDS or undergoing immunosuppressive therapy, who are at increased risk for severe HSV-2 infections.

2. Procedure

The procedure for testing antibodies to herpes simplex virus type 2 (HSV-2) involves several key steps:

  • Sample Collection A blood sample is typically drawn from a vein in the arm or, in some cases, cerebrospinal fluid may be collected if neurological involvement is suspected. The sample is then prepared for analysis.
  • Testing Methodology The laboratory employs one of several testing methods, such as indirect hemagglutination (IHA), chemiluminescent immunoassay, or enzyme-linked immunosorbent assay (ELISA), to detect the presence of antibodies specific to HSV-2. Each method has its own sensitivity and specificity profiles.
  • IgG and IgM Testing Both immunoglobulin G (IgG) and immunoglobulin M (IgM) tests may be performed to assess the immune response. IgM antibodies typically indicate a recent infection, while IgG antibodies suggest past exposure or infection.
  • Result Interpretation After the testing is completed, the laboratory analyzes the results to determine the presence and levels of HSV-2 antibodies. The results are then reported to the healthcare provider for clinical interpretation and further management.

3. Post-Procedure

After the antibody testing for HSV-2, patients may not require any specific post-procedure care, as the blood draw is a routine procedure with minimal risk. However, it is essential for healthcare providers to discuss the results with patients, especially if the test indicates a positive result for HSV-2 antibodies. Patients may need counseling regarding the implications of the results, potential treatment options, and preventive measures to reduce the risk of transmission. Follow-up testing may be necessary in certain cases, particularly if there are concerns about acute infection or if the patient is immunocompromised. Additionally, healthcare providers should ensure that patients understand the importance of regular screenings and monitoring for HSV-2, especially in high-risk populations.

Short Descr HERPES SIMPLEX TYPE 2 TEST
Medium Descr ANTIBODY HERPES SMPLX TYPE 2
Long Descr Antibody; herpes simplex, type 2
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
SA Nurse practitioner rendering service in collaboration with a physician
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
2001-01-01 Added First appearance in code book in 2001.
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