CPT® Code 86635

The CPT® Code 86635 refers to a laboratory test specifically designed to measure antibodies against Coccidioides, a type of fungus that can lead to an infection known as coccidioidomycosis, commonly referred to as Valley Fever. This fungus is predominantly found in soil in certain regions, including the Southwestern United States, parts of Mexico, and Central and South America. The infection occurs when individuals inhale airborne spores, which can result in flu-like symptoms. The incubation period for this infection typically ranges from 1 to 3 weeks, and it is noteworthy that many individuals may not exhibit any signs or symptoms during this time. When symptoms do occur, they can include fever, fatigue, cough, headache, night sweats, muscle and joint pain, and occasionally a rash on the upper body and legs. The presence of Coccidioides antibodies in the blood can indicate either a past or present infection. Specifically, Coccidioides IgM antibodies are usually detectable by the second week of infection but tend to disappear within four months; however, they may reappear in cases of relapse or persist in disseminated infections. On the other hand, IgG antibodies typically appear by the third week of infection and can remain elevated for many years, indicating a longer-term immune response. The test involves obtaining a blood sample through a procedure known as venipuncture, which is reported separately. The serum obtained from the blood sample is then analyzed for the presence of Coccidioides antibodies (both IgM and IgG) using methods such as semi-quantitative complement fixation or semi-quantitative enzyme-linked immunosorbent assay (ELISA), as well as qualitative immunodiffusion for Coccidioides immitis antibodies.