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The CPT® Code 86215 refers to a laboratory test that measures the presence of deoxyribonuclease (DNase) antibodies in the blood. DNase antibodies are specific enzymes that are produced by certain strains of beta-hemolytic streptococcus, a type of bacteria known to cause various infections. This blood test is particularly useful in the context of diagnosing streptococcal infections, especially when traditional tests such as antistreptolysin O (ASO) titers do not show elevated levels. It is important to note that DNase antibodies tend to rise more slowly compared to ASO antibodies and can remain elevated for a longer duration, making this test valuable in specific clinical scenarios. For instance, it may assist in diagnosing conditions such as Sydenham's chorea, which is a neurological disorder associated with rheumatic fever, post-streptococcal rheumatic fever itself, or glomerulonephritis, which is an inflammation of the kidney. The test is performed by obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. The serum obtained from the blood sample is then analyzed using a technique called quantitative nephelometry, which allows for the precise measurement of the DNase antibody levels in the serum.
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The CPT® Code 86215 is indicated for use in specific clinical situations where the presence of deoxyribonuclease (DNase) antibodies may aid in diagnosis. The following conditions are explicitly mentioned as indications for this test:
The procedure for obtaining the results of CPT® Code 86215 involves several key steps that ensure accurate measurement of DNase antibody levels. The following procedural steps are outlined:
After the procedure for CPT® Code 86215, the patient may be advised on standard post-venipuncture care, which includes applying pressure to the puncture site to minimize bleeding and potentially applying a bandage. There are typically no specific post-procedure restrictions, and patients can resume normal activities unless otherwise directed by their healthcare provider. The results of the DNase antibody test will be interpreted by the physician in conjunction with clinical findings and other laboratory results to make an accurate diagnosis.
| Short Descr | DEOXYRIBONUCLEASE ANTIBODY | Medium Descr | DEOXYRIBONUCLEASE ANTIBODY | Long Descr | Deoxyribonuclease, antibody | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 235 - Other Laboratory |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | Q4 | Service for ordering/referring physician qualifies as a service exemption |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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