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CPT®
86590

CPT® Code 86590

Official Description

Streptokinase, antibody

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86590 refers to a laboratory test that measures the presence of streptokinase antibodies in the blood. Streptokinase is an enzyme that is produced by specific strains of streptococcus bacteria and plays a crucial role in the process of thrombolysis, which is the breakdown of blood clots. This enzyme works by converting plasminogen, a precursor protein, into plasmin, the active enzyme that dissolves fibrin clots. The presence of streptokinase antibodies in a patient's blood can indicate an immune response to streptokinase, which may lead to resistance against its anticoagulant effects. This resistance can result in suboptimal outcomes during thrombolytic therapy, where the goal is to effectively dissolve blood clots. To perform this test, a blood sample is collected through a procedure known as venipuncture, which is reported separately. The analysis of the sample is typically conducted using either a rapid latex-bead assay or an enzyme immunoassay, both of which are methods designed to detect the specific antibodies present in the blood.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The test coded as CPT® 86590 is indicated for the assessment of streptokinase antibodies in patients who may have undergone thrombolytic therapy or are being considered for such treatment. The presence of these antibodies can be significant in the following scenarios:

  • Thrombolytic Therapy Evaluation This test is performed to evaluate patients who have received streptokinase as part of their treatment for conditions such as myocardial infarction or pulmonary embolism, to determine if they have developed antibodies that could hinder the effectiveness of the therapy.
  • Resistance Assessment It is indicated for patients who exhibit resistance to thrombolytic therapy, as the presence of streptokinase antibodies may contribute to this resistance, impacting treatment outcomes.
  • Monitoring The test may also be used to monitor patients who have previously been treated with streptokinase to assess the potential for future thrombolytic therapy.

2. Procedure

The procedure for obtaining a streptokinase antibody test involves several key steps, which are outlined below:

  • Step 1: Patient Preparation Prior to the blood draw, the healthcare provider may provide instructions to the patient regarding any necessary preparations, such as fasting or avoiding certain medications that could affect the test results.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture, which involves inserting a needle into a vein, typically in the arm, to collect a blood sample. This step is crucial as the quality of the sample can affect the accuracy of the test results.
  • Step 3: Sample Handling Once the blood sample is collected, it is properly labeled and handled according to laboratory protocols to ensure its integrity during transport to the testing facility.
  • Step 4: Laboratory Testing The blood sample is analyzed using either a rapid latex-bead assay or an enzyme immunoassay. These methods are designed to detect and quantify the presence of streptokinase antibodies in the sample.
  • Step 5: Result Interpretation After testing, the results are interpreted by a qualified laboratory professional, and the findings are reported to the requesting physician, who will use the information to guide further treatment decisions.

3. Post-Procedure

After the venipuncture procedure, patients may experience minor discomfort or bruising at the site of the blood draw, which typically resolves quickly. There are no specific post-procedure care instructions related to the streptokinase antibody test itself; however, patients should be advised to monitor the site for any unusual symptoms, such as excessive bleeding or signs of infection. The results of the test will be communicated to the healthcare provider, who will discuss the implications of the findings and any necessary follow-up actions based on the patient's clinical situation.
Short Descr STREPTOKINASE ANTIBODY
Medium Descr STREPTOKINASE ANTIBODY
Long Descr Streptokinase, antibody
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 235 - Other Laboratory
Date
Action
Notes
2011-01-01 Changed Short description changed.
Pre-1990 Added Code added.
Code
Description
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