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A Streptococcus pneumoniae antibody (IgG), serotypes, multiplex immunoassay is a diagnostic test designed to evaluate the immune response to various serotypes of the bacterium Streptococcus pneumoniae, which is known to be a significant cause of pneumonia, sepsis, and meningitis. This test specifically measures the levels of immunoglobulin G (IgG) antibodies in the blood serum that are directed against multiple serotypes of the pathogen. The multiplex nature of the immunoassay allows for the simultaneous analysis of several serotypes, providing a comprehensive overview of the patient's immune response. The test is particularly useful in monitoring the effectiveness of pneumococcal vaccination, as it helps determine whether the vaccine has successfully stimulated the production of antibodies. Additionally, it can be employed to assess humoral immunodeficiency, a condition where the body’s ability to produce antibodies is compromised. The procedure involves collecting a blood serum sample, which is then subjected to a microsphere photometry test or bead-based multiplex immunoassay. In this process, the pneumococcal target antigens are attached to magnetic beads that capture the specific antibodies present in the serum. Following this, an anti-human IgG antibody is introduced to identify and quantify the bound antibodies and antigens, thereby allowing for the assessment of the patient's immune response to the pathogen. The results of this test are quantitatively expressed, with values greater than 270 mcg/mL indicating a robust vaccine response, while values below 9.7 mcg/mL suggest inadequate antibody production.
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The Streptococcus pneumoniae antibody (IgG), serotypes, multiplex immunoassay is indicated for the following conditions:
The procedure for conducting the Streptococcus pneumoniae antibody (IgG), serotypes, multiplex immunoassay involves several key steps:
Post-procedure care for the patient is generally minimal, as the test is non-invasive and involves only a blood draw. Patients may be advised to hydrate adequately and can typically resume normal activities immediately following the procedure. Results from the immunoassay will be analyzed and reported, indicating the levels of IgG antibodies present. A result greater than 270 mcg/mL suggests a strong immune response to the pneumococcal vaccine, while a result below 9.7 mcg/mL indicates poor antibody production, which may necessitate further clinical evaluation or intervention.
| Short Descr | STRPTCS PNEUM ANTB SEROT IA | Medium Descr | STRPTCS PNEUM ANTIBODY IGG SEROTYPES MLT IA QUAN | Long Descr | Streptococcus pneumoniae antibody (IgG), serotypes, multiplex immunoassay, quantitative | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | none | MUE | Not applicable/unspecified. |
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| 2025-01-01 | Added | Code Added. |
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