CPT® Code 86235

The CPT® Code 86235 refers to a laboratory test that measures the presence of antibodies to extractable nuclear antigens (ENAs) in a blood sample. These antibodies are proteins produced by the immune system that can mistakenly target the body's own tissues, which is a hallmark of autoimmune diseases. The test can detect various specific antibodies, including but not limited to nRNP, SS-A, SS-B, Sm, RNP, Sc170, and Jo-1. Elevated levels of these antibodies are often associated with conditions such as Sjogren's syndrome, polymyositis, systemic lupus erythematosus, and progressive systemic sclerosis. The procedure typically involves obtaining a blood sample through venipuncture, which is a separate reportable service. The testing can be performed using various methods, with semiquantitative multi-analyte fluorescent detection being a common approach. Each antibody detected is reported individually, allowing for a comprehensive assessment of the patient's autoimmune status.