CPT® Code 86343

The Leukocyte Histamine Release Test (LHR), identified by CPT® Code 86343, is a diagnostic procedure that evaluates the immune response of peripheral blood leukocytes to specific allergens. This test quantifies the histamine released from these white blood cells when exposed to various concentrations of an allergen extract. Histamine is a chemical involved in local immune responses, and its release indicates a hypersensitivity reaction to the allergen. In individuals with an allergy, the leukocytes will release histamine upon exposure to the allergen, which can be measured in the laboratory. It is important to note that the test is limited in that only a select number of allergens can be tested simultaneously within a single blood sample. Additionally, there is inherent variability in the measurement of histamine levels, which can affect the reliability of the results. Due to these factors, the LHR test may be regarded as investigational by many insurance policies, reflecting the ongoing debate regarding its clinical utility and standardization in allergy testing.