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Official Description

Growth hormone, human (HGH), antibody

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86277 refers to a laboratory test that measures the levels of antibodies against human growth hormone (HGH) in the blood. This test is particularly relevant for individuals who are undergoing treatment with recombinant human growth hormone (rhGH), as these patients may develop antibodies that can neutralize the effects of the administered growth hormone. The presence of these antibodies can significantly impact the efficacy of the treatment, making it essential to monitor their levels regularly. The test involves obtaining a blood sample through a procedure known as venipuncture, which is reported separately. The serum obtained from the blood sample is then analyzed using a radiobinding assay, a specific laboratory technique that allows for the accurate measurement of the antibody levels. This test is crucial for healthcare providers to assess the patient's response to rhGH therapy and to make informed decisions regarding ongoing treatment plans.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The test coded as CPT® 86277 is indicated for the following conditions:

  • Monitoring Treatment Efficacy This test is performed to evaluate the presence of antibodies against human growth hormone in patients receiving recombinant human growth hormone (rhGH) therapy.
  • Assessment of Antibody Development It is used to determine if patients have developed antibodies that may neutralize the effects of rhGH, which can affect treatment outcomes.
  • Regular Monitoring The test may be ordered at regular intervals to track changes in antibody levels during the course of rhGH treatment.

2. Procedure

The procedure for conducting the test associated with CPT® 86277 involves several key steps:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to follow specific guidelines, such as fasting or avoiding certain medications, although these instructions are not explicitly detailed in the provided data.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to collect the necessary volume of blood for testing. The procedure is performed using sterile techniques to minimize the risk of infection.
  • Step 3: Serum Separation After the blood sample is collected, it is processed to separate the serum from the cellular components. This is typically done by centrifugation, which spins the blood at high speeds to separate the different components based on density.
  • Step 4: Radiobinding Assay The serum is then subjected to a radiobinding assay, a laboratory technique that utilizes radioactive isotopes to detect and quantify the levels of human growth hormone antibodies present in the serum sample.

3. Post-Procedure

After the procedure, the patient may experience minor discomfort or bruising at the venipuncture site, which is generally temporary. There are no specific post-procedure care instructions provided in the data; however, patients are typically advised to keep the site clean and dry. The results of the test will be analyzed and reported to the healthcare provider, who will use this information to assess the patient's response to rhGH therapy and make any necessary adjustments to the treatment plan.

Short Descr GROWTH HORMONE ANTIBODY
Medium Descr GROWTH HORMONE HUMAN ANTIBODY
Long Descr Growth hormone, human (HGH), antibody
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
Pre-1990 Added Code added.
Code
Description
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