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The CPT® Code 86353 refers to a laboratory procedure known as lymphocyte transformation, specifically focusing on mitogen (phytomitogen) or antigen-induced blastogenesis. This test is designed to evaluate the functional capacity of T-lymphocytes, which are a critical component of the immune system. By measuring the transformation of lymphocytes in response to specific stimuli, such as mitogens or antigens, healthcare providers can gain insights into the immune response of a patient. This is particularly important for individuals who may have compromised immune systems due to various factors, including immunosuppressive therapy following organ transplantation or conditions that lead to immune deficiency, whether disease-related or iatrogenic. The test is also valuable in monitoring the recovery and functionality of T-cells after procedures like bone marrow or stem cell transplants. It assesses how well the immune system is responding to these interventions. The procedure involves obtaining a blood sample through venipuncture, which is reported separately, and then testing the whole blood using cell culture techniques to observe the proliferation of lymphocytes in response to the applied mitogens or antigens. This comprehensive evaluation helps in understanding the immune status of patients and guiding further clinical decisions.
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The lymphocyte transformation test coded as CPT® 86353 is indicated for several specific clinical scenarios, particularly those involving immune system assessment and monitoring. The following conditions and situations warrant the use of this test:
The procedure for lymphocyte transformation testing involves several key steps that ensure accurate assessment of T-cell function. The following outlines the procedural steps involved:
After the lymphocyte transformation test is completed, there are no specific post-procedure care requirements mentioned. However, it is important for healthcare providers to monitor the patient for any potential reactions to the venipuncture site, such as bruising or discomfort. The results of the test will be interpreted in the context of the patient's overall clinical picture, and follow-up may be necessary to discuss the findings and any further actions required based on the immune assessment.
| Short Descr | LYMPHOCYTE TRANSFORMATION | Medium Descr | LYMPHOCYTE TR MITOGEN/AG INDUCED BLASTOGENESIS | Long Descr | Lymphocyte transformation, mitogen (phytomitogen) or antigen induced blastogenesis | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 7 | CCS Clinical Classification | 235 - Other Laboratory |
| GA | Waiver of liability statement issued as required by payer policy, individual case | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GZ | Item or service expected to be denied as not reasonable and necessary | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit |
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| Pre-1990 | Added | Code added. |
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