CPT® Code 86353

The CPT® Code 86353 refers to a laboratory procedure known as lymphocyte transformation, specifically focusing on mitogen (phytomitogen) or antigen-induced blastogenesis. This test is designed to evaluate the functional capacity of T-lymphocytes, which are a critical component of the immune system. By measuring the transformation of lymphocytes in response to specific stimuli, such as mitogens or antigens, healthcare providers can gain insights into the immune response of a patient. This is particularly important for individuals who may have compromised immune systems due to various factors, including immunosuppressive therapy following organ transplantation or conditions that lead to immune deficiency, whether disease-related or iatrogenic. The test is also valuable in monitoring the recovery and functionality of T-cells after procedures like bone marrow or stem cell transplants. It assesses how well the immune system is responding to these interventions. The procedure involves obtaining a blood sample through venipuncture, which is reported separately, and then testing the whole blood using cell culture techniques to observe the proliferation of lymphocytes in response to the applied mitogens or antigens. This comprehensive evaluation helps in understanding the immune status of patients and guiding further clinical decisions.