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The CPT® Code 87475 refers to a laboratory test designed for the detection of the infectious agent Borrelia burgdorferi through nucleic acid analysis, specifically targeting DNA or RNA. Borrelia burgdorferi is a bacterium that is primarily transmitted to humans via the bite of an infected black-legged tick, and it is widely recognized as the causative agent of Lyme disease. This test is particularly valuable in clinical scenarios where Lyme disease is highly suspected, yet serological tests yield negative results. The nucleic acid detection method employed in this procedure utilizes a direct probe technique, which focuses on identifying a unique nucleic acid sequence known as the target sequence of the B. burgdorferi organism. This identification process can occur in various biological samples, including blood, tissue, cerebrospinal fluid (CSF), or synovial fluid. The direct probe used in this test is labeled with either fluorescent or chemiluminescent markers, enhancing the visibility of the target sequence. To facilitate the detection of the nucleic acids, the sample undergoes treatment that releases nucleic acids from the target organism, if present. The labeled probe then specifically binds to the matching target sequence, forming a stable hybrid that can be detected. Notably, ribosomal RNA is often the focus of this detection method, as it exists in numerous copies within most microorganisms, in contrast to the limited copies found in genomic DNA. For enhanced sensitivity, an amplified probe technique, referenced by CPT® Code 87476, can be utilized, which involves exponentially multiplying the target sequence of B. burgdorferi DNA or RNA into millions of copies. The most prevalent amplification methods include polymerase chain reaction (PCR) and reverse transcriptase polymerase chain reaction (RT-PCR), which allow for the identification of the replicated sequences using labeled DNA probes.
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The CPT® Code 87475 is indicated for use in specific clinical scenarios where the detection of Borrelia burgdorferi is necessary. The following conditions warrant the performance of this laboratory test:
The procedure for CPT® Code 87475 involves several critical steps to ensure accurate detection of Borrelia burgdorferi. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87475, the laboratory will analyze the results and report the findings. It is essential for healthcare providers to interpret the results in conjunction with clinical symptoms and other diagnostic information. If B. burgdorferi is detected, appropriate treatment options for Lyme disease may be considered. Additionally, healthcare providers should monitor the patient for any potential complications or further symptoms that may arise following the initial diagnosis. Follow-up testing may be necessary to assess treatment efficacy or to monitor for any recurrence of symptoms.
| Short Descr | LYME DIS DNA DIR PROBE | Medium Descr | IADNA BORRELIA BURGDORFERI DIRECT PROBE TQ | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); Borrelia burgdorferi, direct probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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