CPT® Code 87625

Infectious agent detection by nucleic acid (DNA or RNA); Human Papillomavirus (HPV), types 16 and 18 only, includes type 45, if performed

The CPT® Code 87625 pertains to the detection of infectious agents through nucleic acid testing, specifically targeting the Human Papillomavirus (HPV). This code is utilized for identifying HPV types 16 and 18, which are recognized as high-risk oncogenic strains associated with cervical cancer. Additionally, this code encompasses type 45 if it is included in the testing process. HPV is a virus that can invade the skin and mucosal epithelia, leading to both clinical and subclinical infections. There are over 100 known types of HPV, with approximately 40 types affecting the anogenital region. High-risk HPV types, particularly types 16 and 18, are often found in high-grade squamous intraepithelial lesions (HSIL) and invasive cancers, while low-risk types are linked to conditions such as acuminate condylomas and low-grade squamous intraepithelial lesions (LSIL) of the cervix. The detection of HPV through nucleic acid testing has become a standard practice in managing cervical disease in women, allowing for timely diagnosis and intervention. The testing process involves collecting exfoliated cervical cells, which are then treated and analyzed to identify the presence of specific HPV types, thereby aiding in the assessment of cervical health and cancer risk.