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Official Description

Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) and influenza virus types A and B, multiplex amplified probe technique

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 87636 refers to a diagnostic procedure that detects infectious agents through nucleic acid analysis, specifically targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease (COVID-19), as well as influenza virus types A and B. This procedure employs a multiplex amplified probe technique, allowing for the simultaneous identification of multiple viral pathogens from a single sample. The method is particularly valuable in clinical settings where rapid and accurate diagnosis is crucial, especially given the overlapping symptoms of these respiratory illnesses. The multiplex approach enables healthcare providers to determine the presence of COVID-19 and influenza viruses concurrently, facilitating timely and appropriate treatment decisions. The underlying technology involves amplifying specific segments of viral DNA or RNA, which enhances the detection of even minimal amounts of genetic material. This is essential for accurate diagnosis, as respiratory samples may contain low viral loads. The procedure is performed on respiratory specimens collected from patients, ensuring that the testing process is both efficient and effective in identifying the causative agents of respiratory infections.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 87636 is indicated for the detection of specific viral infections, particularly in patients presenting with respiratory symptoms. The following conditions warrant the use of this multiplex testing procedure:

  • COVID-19 Diagnosis of SARS-CoV-2 infection in patients exhibiting symptoms consistent with coronavirus disease.
  • Influenza A and B Identification of influenza virus types A and B in patients with respiratory illness, allowing for differentiation from COVID-19.
  • Co-infection Assessment Evaluation of patients who may be co-infected with both SARS-CoV-2 and influenza viruses, aiding in comprehensive management of respiratory illnesses.

2. Procedure

The procedure for CPT® Code 87636 involves several critical steps to ensure accurate detection of the targeted viruses. Each step is essential for the successful amplification and identification of viral nucleic acids:

  • Sample Collection A respiratory sample is obtained from the patient, which may include sputum, nasal swabs, throat swabs, bronchial aspirates, or bronchoalveolar lavage. This step is crucial as it provides the biological material needed for testing.
  • Sample Preparation The collected sample undergoes treatment with various chemical solutions designed to eliminate fats and proteins, thereby isolating the RNA present in the sample. This process ensures that both the patient's RNA and any viral RNA are accessible for further analysis.
  • Reverse Transcription Since SARS-CoV-2 is an RNA virus, the RNA must be converted into DNA for amplification. This is achieved through a reverse transcription process, where a specific enzyme is added to facilitate the conversion of RNA into complementary DNA (cDNA).
  • Probe and Primer Addition Oligonucleotide probes and primers, which are tagged with fluorescent dyes, are introduced to the sample. These probes specifically bind to the target nucleic acid sequences, marking them for amplification.
  • Amplification The sample is placed in a real-time reverse transcription-polymerase chain reaction (RT-PCR) machine. The machine cycles through a series of chemical reactions that exponentially amplify the target DNA segments. Each cycle doubles the amount of DNA, significantly increasing the quantity available for detection.
  • Fluorescence Measurement As the amplification progresses, the fluorescent markers attached to the newly created DNA copies emit signals that are measured in real time by the RT-PCR machine. The detection of fluorescence indicates the presence of the targeted viruses.
  • Confirmation of Presence A specific threshold of fluorescence must be reached to confirm the presence of the viruses. The number of cycles required to achieve this threshold can also provide insights into the viral load and potential disease severity.

3. Post-Procedure

After the completion of the testing procedure associated with CPT® Code 87636, the results are analyzed and interpreted by qualified healthcare professionals. The expected outcome is a clear indication of whether SARS-CoV-2, influenza A, or influenza B viruses are present in the sample. Depending on the results, appropriate clinical actions may be taken, including treatment initiation, patient isolation, or further diagnostic testing. It is essential for healthcare providers to communicate the results to the patient promptly and to discuss any necessary follow-up care or interventions based on the findings. Additionally, proper documentation of the procedure and results is crucial for compliance and billing purposes.

Short Descr SARSCOV2 & INF A&B AMP PRB
Medium Descr IADNA SARSCOV2& INF A&B MULT AMPLIFIED PROBE TQ
Long Descr Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) and influenza virus types A and B, multiplex amplified probe technique
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) Yes
APC Status Indicator Service Paid under Fee Schedule or Payment System other than OPPS
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) none
MUE 1
QW Clia waived test
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GZ Item or service expected to be denied as not reasonable and necessary
CR Catastrophe/disaster related
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GW Service not related to the hospice patient's terminal condition
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
GC This service has been performed in part by a resident under the direction of a teaching physician
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CS Cost-sharing waived for specified covid-19 testing-related services that result in and order for or administration of a covid-19 test and/or used for cost-sharing waived preventive services furnished via telehealth in rural health clinics and federally qualified health centers during the covid-19 public health emergency
HW Funded by state mental health agency
KX Requirements specified in the medical policy have been met
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
U7 Medicaid level of care 7, as defined by each state
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2022-01-01 Added First appearance of code in codebook.
2022-01-01 Note Grammar correction
2021-01-01 Added First appearance of code in CPT® Code Set.
2020-10-06 Added Code added.
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