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The CPT® Code 87653 refers to the detection of infectious agents through nucleic acid testing, specifically targeting Streptococcus, group B, using an amplified probe technique. This method is a significant advancement in diagnostic microbiology, providing a reliable alternative to traditional culturing methods. Nucleic acid detection focuses on identifying the genetic material—either DNA or RNA—of the infectious agent, which allows for the detection of much lower levels of the organism, sometimes down to a single cell. The process involves the release of the infectious agent's nucleic acids from the cells, followed by their extraction through a technique known as nucleic acid hybridization. This technique utilizes a specially designed probe, which consists of laboratory-prepared complementary strands of nucleic acid that are often labeled with chemical fluorescence. These probes are engineered to bind specifically to the target DNA, forming stable double-stranded complexes or hybrids. The amplified probe technique enhances the sensitivity of the test, enabling more direct and qualitative detection of the infectious agent. This is achieved through methods such as polymerase chain reaction (PCR), which enzymatically replicates specific target sequences within the DNA, resulting in exponential amplification of the genetic material. In this process, amplification primers—short strands of DNA that are complementary to the target DNA—are used alongside the probe. These primers attach to the target DNA at designated points, allowing the polymerase enzyme to copy the region and synthesize new DNA, thereby increasing the amount of detectable genetic material in the sample.
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The CPT® Code 87653 is indicated for the detection of Streptococcus, group B, in patients who may present with symptoms or conditions associated with this infectious agent. The following are specific indications for performing this procedure:
The procedure for CPT® Code 87653 involves several critical steps to ensure accurate detection of the infectious agent. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87653, the results are typically available within a short timeframe, allowing for timely clinical decision-making. It is essential for healthcare providers to interpret the results in conjunction with clinical findings and patient history. If the test is positive for Streptococcus, group B, appropriate management and treatment protocols should be initiated, particularly in pregnant women to prevent transmission to the newborn. Additionally, healthcare providers should ensure that proper documentation of the procedure and results is maintained for compliance and billing purposes.
| Short Descr | STREP B DNA AMP PROBE | Medium Descr | IADNA STREPTOCOCCUS GROUP B AMPLIFIED PROBE TQ | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); Streptococcus, group B, amplified probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
| 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service | GW | Service not related to the hospice patient's terminal condition | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | XS | Separate structure, a service that is distinct because it was performed on a separate organ/structure | GV | Attending physician not employed or paid under arrangement by the patient's hospice provider | GZ | Item or service expected to be denied as not reasonable and necessary | T5 | Right foot, great toe | T3 | Left foot, fourth digit | RT | Right side (used to identify procedures performed on the right side of the body) | T4 | Left foot, fifth digit | T2 | Left foot, third digit | T9 | Right foot, fifth digit | T1 | Left foot, second digit | LT | Left side (used to identify procedures performed on the left side of the body) | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 56 | Preoperative management only: when 1 physician or other qualified health care professional performed the preoperative care and evaluation and another performed the surgical procedure, the preoperative component may be identified by adding modifier 56 to the usual procedure number. | 58 | Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78. | 76 | Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | 77 | Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | 79 | Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.) | GA | Waiver of liability statement issued as required by payer policy, individual case | GF | Non-physician (e.g. nurse practitioner (np), certified registered nurse anesthetist (crna), certified registered nurse (crn), clinical nurse specialist (cns), physician assistant (pa)) services in a critical access hospital | KX | Requirements specified in the medical policy have been met | Q4 | Service for ordering/referring physician qualifies as a service exemption | QJ | Services/items provided to a prisoner or patient in state or local custody, however the state or local government, as applicable, meets the requirements in 42 cfr 411.4 (b) | QW | Clia waived test | SA | Nurse practitioner rendering service in collaboration with a physician | T6 | Right foot, second digit | T7 | Right foot, third digit | T8 | Right foot, fourth digit | TA | Left foot, great toe | XE | Separate encounter, a service that is distinct because it occurred during a separate encounter | XP | Separate practitioner, a service that is distinct because it was performed by a different practitioner |
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| 2011-01-01 | Changed | Short description changed. |
| 2007-01-01 | Added | First appearance in code book in 2007. |
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