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The CPT® Code 87526 refers to a laboratory test designed for the detection of the hepatitis G virus (HGV), also known as GB virus-C (GBV-C), through the use of nucleic acid amplification techniques. This test specifically targets the viral DNA or RNA, allowing for the identification of the infectious agent in a blood sample. Hepatitis G infection is typically asymptomatic and does not usually lead to significant liver inflammation; however, it can occur alongside other viral infections that may cause acute or chronic hepatitis. The transmission of HGV primarily occurs through exposure to infected blood and blood products, from mother to infant during childbirth, and through sexual contact with an infected individual. The testing process involves a direct probe test, which identifies a unique nucleic acid sequence known as the target sequence of the hepatitis G virus, if present in the sample. This is achieved by using a probe that is labeled with either fluorescent or chemiluminescent markers. The blood sample is treated to release nucleic acids from the virus, and the labeled probe binds specifically to the target sequence, forming a stable hybrid. In the amplified probe technique, the sensitivity of the assay is significantly enhanced by exponentially multiplying the target sequence of the hepatitis G virus DNA or RNA into millions of copies. The most prevalent amplification methods include polymerase chain reaction (PCR) and reverse transcriptase polymerase chain reaction (RT-PCR). Following amplification, the replicated sequences are identified using labeled DNA probes. Additionally, nucleic acid detection with quantification can be performed to assess the quantity of microorganisms present, often utilizing quantitative or real-time PCR to provide detailed reports on the absolute or relative amounts of the nucleic acid sequence detected.
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The CPT® Code 87526 is indicated for the detection of the hepatitis G virus (HGV) in patients who may be at risk for infection. The following conditions and situations warrant the use of this test:
The procedure for CPT® Code 87526 involves several critical steps to ensure accurate detection of the hepatitis G virus. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87526, the laboratory will analyze the results and generate a report detailing the presence of the hepatitis G virus. The results may indicate whether the virus is detected and, if applicable, the quantity of viral nucleic acid present in the sample. Clinicians will use this information to guide further patient management, which may include monitoring for co-infections, counseling on transmission risks, and determining the need for additional testing or treatment. It is important for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions based on the findings.
| Short Descr | HEPATITIS G DNA AMP PROBE | Medium Descr | IADNA HEPATITIS G AMPLIFIED PROBE TECHNIQUE | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); hepatitis G, amplified probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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