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Official Description

Amylase

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82150 refers to the laboratory testing for amylase, an important enzyme involved in the digestive process. Amylase plays a crucial role in the breakdown of complex carbohydrates, specifically starches, into simpler sugar molecules, such as disaccharides and trisaccharides, which are further converted into glucose. This glucose serves as a vital source of energy for the body's cells. The enzyme is primarily produced in two locations: the salivary glands and the pancreas. Testing for amylase can be conducted on various biological samples, including blood, urine, and other body fluids, allowing healthcare providers to assess the enzyme's levels in the body. Abnormal levels of amylase can indicate several medical conditions, including pancreatic inflammation or trauma, perforated peptic ulcers, ovarian cysts (especially in cases of torsion), strangulation ileus, macroamylasemia, mumps, and cystic fibrosis. The testing process involves obtaining a sample of blood or another body fluid, which is then analyzed using quantitative enzymatic methodology to determine the concentration of amylase present.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Laboratory testing for amylase is indicated in various clinical scenarios where abnormal enzyme levels may suggest underlying health issues. The following conditions may warrant amylase testing:

  • Pancreatic Inflammation or Trauma Amylase levels can rise significantly in cases of pancreatitis or pancreatic injury, making this test useful for diagnosis.
  • Perforated Peptic Ulcer Elevated amylase may indicate complications from peptic ulcers, particularly if there is perforation leading to peritoneal irritation.
  • Ovarian Cyst (Torsion) In cases of ovarian torsion, amylase levels may be elevated due to associated inflammatory processes.
  • Strangulation Ileus This condition, where the intestine is obstructed and blood supply is compromised, may also lead to increased amylase levels.
  • Macroamylasemia This condition involves the presence of a complex form of amylase that can lead to elevated test results without indicating pancreatic disease.
  • Mumps Viral infections such as mumps can cause elevated amylase levels due to inflammation of the salivary glands.
  • Cystic Fibrosis Patients with cystic fibrosis may exhibit abnormal amylase levels due to pancreatic dysfunction.

2. Procedure

The procedure for amylase testing involves several key steps to ensure accurate measurement of the enzyme levels in the sample collected. The following procedural steps are typically followed:

  • Step 1: Sample Collection A healthcare professional collects a sample of blood or other body fluids, such as urine, depending on the specific requirements of the test. Proper collection techniques are essential to avoid contamination and ensure the integrity of the sample.
  • Step 2: Sample Preparation Once collected, the sample is prepared for analysis. This may involve centrifugation of blood samples to separate plasma or serum from cellular components, ensuring that only the relevant fluid is tested.
  • Step 3: Testing Methodology The prepared sample is then subjected to quantitative enzymatic methodology. This involves using specific reagents that react with amylase to produce measurable results, typically through spectrophotometric analysis, which quantifies the enzyme concentration based on the intensity of the color change.
  • Step 4: Result Interpretation After the testing is complete, the results are analyzed and interpreted by laboratory personnel. The amylase levels are compared against established reference ranges to determine if they are within normal limits or indicative of a potential medical condition.

3. Post-Procedure

After the amylase testing procedure, there are generally no specific post-procedure care requirements for patients, especially if the sample was collected via a simple blood draw. Patients may resume normal activities immediately following the test. However, it is important for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions based on the findings. If elevated amylase levels are detected, further diagnostic evaluations may be warranted to investigate the underlying cause and determine appropriate treatment options.

Short Descr ASSAY OF AMYLASE
Medium Descr ASSAY OF AMYLASE
Long Descr Amylase
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) Yes
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
QW Clia waived test
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GA Waiver of liability statement issued as required by payer policy, individual case
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
Q4 Service for ordering/referring physician qualifies as a service exemption
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
X1 Continuous/broad services: for reporting services by clinicians, who provide the principal care for a patient, with no planned endpoint of the relationship; services in this category represent comprehensive care, dealing with the entire scope of patient problems, either directly or in a care coordination role; reporting clinician service examples include, but are not limited to: primary care, and clinicians providing comprehensive care to patients in addition to specialty care
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
Q0 Investigational clinical service provided in a clinical research study that is in an approved clinical research study
GZ Item or service expected to be denied as not reasonable and necessary
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
AY Item or service furnished to an esrd patient that is not for the treatment of esrd
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GC This service has been performed in part by a resident under the direction of a teaching physician
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
PN Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
Code
Description
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