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Official Description

Galectin-3

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82777 refers to a laboratory test that measures the levels of galectin-3, a protein that plays a significant role in the body's response to cardiac muscle injury. This blood test is particularly relevant for patients who have been identified as having sustained damage to their heart muscle. Galectin-3 is known to activate various cellular processes following cardiac injury, and its elevated levels can indicate the presence of excessive scarring and fibrosis within the heart tissue. Such conditions can lead to adverse remodeling of the heart, which is characterized by changes in its shape and dimensions, ultimately contributing to chronic heart failure. The test is performed by obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. The analysis of the serum or plasma is conducted using a specific laboratory technique called enzyme-linked immunosorbent assay (ELISA), which allows for the accurate quantification of galectin-3 levels in the sample.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The galectin-3 blood test (CPT® Code 82777) is indicated for use in patients who have been identified with cardiac muscle injury. The following conditions and symptoms may warrant the performance of this test:

  • Cardiac Muscle Injury: Patients who have experienced damage to the heart muscle, which may be due to various underlying conditions such as myocardial infarction or other forms of cardiac stress.
  • Chronic Heart Failure: Individuals diagnosed with chronic heart failure may be evaluated for galectin-3 levels to assess the extent of fibrosis and adverse remodeling of the heart.
  • Monitoring Cardiac Conditions: The test may be used to monitor patients with existing cardiac conditions to evaluate the progression of heart disease and the effectiveness of treatment interventions.

2. Procedure

The procedure for measuring galectin-3 levels involves several key steps, which are outlined as follows:

  • Step 1: Patient Preparation Before the blood test is conducted, the patient may be instructed to follow specific guidelines, such as fasting or avoiding certain medications that could affect the results. It is essential to ensure that the patient is adequately prepared for the venipuncture procedure.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves using a sterile needle to access a vein, typically in the arm, and collecting the blood into a designated collection tube. The procedure is performed with aseptic technique to minimize the risk of infection.
  • Step 3: Sample Processing Once the blood sample is collected, it is processed to separate the serum or plasma from the cellular components. This may involve centrifugation of the sample to ensure that the liquid portion is ready for analysis.
  • Step 4: Laboratory Analysis The processed serum or plasma is then subjected to analysis using the enzyme-linked immunosorbent assay (ELISA) method. This laboratory technique allows for the specific detection and quantification of galectin-3 levels in the sample, providing valuable information regarding the patient's cardiac status.

3. Post-Procedure

After the blood sample has been collected and processed, there are generally no specific post-procedure care requirements for the patient. However, it is advisable for the patient to remain hydrated and to monitor the venipuncture site for any signs of complications, such as excessive bleeding or bruising. The results of the galectin-3 test will be interpreted by the healthcare provider in conjunction with the patient's clinical history and other diagnostic findings to inform treatment decisions and management of cardiac conditions.

Short Descr GALECTIN-3
Medium Descr GALECTIN-3
Long Descr Galectin-3
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GA Waiver of liability statement issued as required by payer policy, individual case
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
Date
Action
Notes
2013-01-01 Added Added
Code
Description
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