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The CPT® Code 83006 refers to a laboratory test that measures the growth stimulation expressed gene 2, commonly known as ST2, which is a member of the interleukin 1 receptor family. This biomarker exists in two distinct forms: soluble ST2 (sST2) and transmembrane-bound ST2-ligand (ST2L). The presence and levels of ST2 in the body can provide critical insights into a patient's cardiac health. Specifically, when utilized alongside clinical evidence, the measurement of ST2 can assist healthcare professionals in predicting adverse outcomes and mortality in patients who have experienced documented cardiac injury or stress. Furthermore, ST2 serves as a prognostic marker for potential future cardiac diseases within the general population. In response to cardiac injury or stress, healthy cardiac tissue produces sST2, which subsequently binds to interleukin-33 (IL-33). This binding action diminishes the protective effects of the ST2L receptor, which is crucial for safeguarding against myocardial fibrosis and heart failure. The testing of serum or plasma samples for ST2 levels is conducted using the enzyme-linked immunosorbent assay (ELISA) method, a widely recognized laboratory technique that allows for the accurate quantification of this biomarker.
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The laboratory test associated with CPT® Code 83006 is indicated for the following conditions:
The procedure for testing ST2 levels involves several key steps that ensure accurate measurement and analysis of the biomarker:
Post-procedure care for patients undergoing the ST2 test is generally minimal, as the test involves a standard blood draw. Patients may experience slight discomfort or bruising at the puncture site, which typically resolves quickly. There are no specific restrictions or follow-up procedures required after the test, and patients can resume their normal activities immediately. However, it is essential for healthcare providers to discuss the results with patients once they are available, as this will guide further management and treatment decisions based on the ST2 levels and the clinical context.
| Short Descr | GROWTH STIMULATION GENE 2 | Medium Descr | GROWTH STIMULATION EXPRESSED GENE 2 | Long Descr | Growth stimulation expressed gene 2 (ST2, Interleukin 1 receptor like-1) | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2015-01-01 | Added | Added |
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