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Official Description

Selenium

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 84255 refers to the measurement of selenium levels in the body through a blood or urine test. Selenium is classified as a trace mineral, which means it is required by the body in small amounts for various physiological functions. This mineral plays a crucial role in maintaining optimum health, as it is involved in antioxidant defense, thyroid hormone metabolism, and immune function. Selenium is naturally found in a variety of foods, particularly in plants and seafood, and its availability can vary significantly depending on the geographical region. A deficiency in selenium can lead to several health issues, including heart disease, thyroid dysfunction, and a compromised immune system. Specific diseases associated with selenium deficiency include Keshan disease, which affects the heart; Kashin-Beck disease, which impacts joint health; and Myxedematous Endemic Cretinism, a severe form of hypothyroidism. To perform the test, a blood sample is typically collected through a venipuncture, which is a procedure that may need to be reported separately. Alternatively, a urine sample can be collected over a 24-hour period to assess selenium levels. The analysis of serum, plasma, or urine samples is conducted using a sophisticated technique known as quantitative inductively coupled plasma-mass spectrometry, which allows for precise measurement of selenium concentrations.

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