CPT® Code 82595

The CPT® Code 82595 refers to the qualitative or semi-quantitative testing of cryoglobulins, commonly known as cryocrit. This procedure involves analyzing a blood sample to determine the presence or absence of cryoglobulins, which are abnormal proteins that can precipitate in the blood at low temperatures. The qualitative aspect of the test simply identifies whether cryoglobulins are present, while the semi-quantitative aspect provides an estimate of their concentration in the sample. Cryoglobulins are often associated with various medical conditions, including plasma cell and lymphoproliferative disorders, collagen vascular diseases, hepatitis C, infectious mononucleosis, and cytomegalovirus disease. To perform this test, a blood sample is collected through a venipuncture, which is a separately reportable procedure. The testing process involves cold precipitation techniques, and the sample is monitored daily over a period of 3 to 5 days to detect any evidence of cryoglobulins. This thorough examination is crucial for diagnosing and managing the aforementioned conditions effectively.