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The CPT® Code 83080 refers to the laboratory test for measuring b-Hexosaminidase levels in serum and leukocytes. This test is crucial for assessing the activity of the b-Hexosaminidase enzyme, which plays a significant role in the hydrolysis of hexosamine. Hexosaminidase exists in three functional lysosomal forms: Hex A, Hex B, and Hex S. Hex A is particularly important as its deficiency is associated with Tay-Sachs disease and its variants, while a total deficiency of both Hex A and Hex B is indicative of Sandhoff disease and its variants. Hex S, on the other hand, is a minor component and does not contribute to the pathology of Sandhoff disease. The test involves obtaining a blood sample through venipuncture, which is a separately reportable procedure. The serum is analyzed using heat inactivation combined with fluorometric and automated techniques, while leukocytes are tested using heat inactivation with fluorometric and semiautomated methods. Each assay performed for b-Hexosaminidase levels should be reported using the code 83080.
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The b-Hexosaminidase assay is performed for specific clinical indications related to lysosomal storage disorders. The following conditions may warrant this test:
The procedure for conducting the b-Hexosaminidase assay involves several key steps to ensure accurate measurement of enzyme levels:
After the b-Hexosaminidase assay is completed, the results are analyzed and interpreted by a qualified healthcare professional. Depending on the findings, further diagnostic testing or genetic counseling may be recommended, especially if a lysosomal storage disorder is suspected. Patients may be advised on follow-up appointments to discuss the results and any necessary treatment options. It is important to ensure that the results are documented accurately for future reference and potential clinical decision-making.
| Short Descr | ASSAY OF B HEXOSAMINIDASE EA | Medium Descr | ASSAY OF B-HEXOSAMINIDASE EACH ASSAY | Long Descr | b-Hexosaminidase, each assay | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 2 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2023-01-01 | Note | Short description changed. |
| 2013-01-01 | Changed | Medium Descriptor changed. |
| 1999-01-01 | Added | First appearance in code book in 1999. |
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