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Official Description

Androstenedione

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82157 refers to a laboratory test specifically designed to measure the levels of androstenedione in the blood. Androstenedione is a steroid hormone that plays a crucial role in the production of other hormones, particularly androgens and estrogens. It is synthesized primarily in the adrenal glands and serves as a precursor to testosterone in males and to estrone and estradiol in females. This test is particularly significant in clinical settings where there is a need to evaluate hormonal imbalances or conditions related to abnormal androgen levels. The measurement of androstenedione is essential for diagnosing virilizing syndromes in women, which are characterized by the development of male physical traits due to elevated androgen levels. Additionally, this test is utilized in cases where there is a suspicion of anabolic steroid abuse, as elevated levels of androstenedione may indicate the use of performance-enhancing substances. The procedure involves obtaining a blood sample through venipuncture, which is a separate reportable service, and the analysis of the sample is conducted using advanced techniques such as quantitative high performance liquid chromatography-tandem mass spectrometry, ensuring accurate and reliable results.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The androstenedione test (CPT® Code 82157) is indicated for specific clinical scenarios where hormonal evaluation is necessary. The following conditions warrant the performance of this test:

  • Virilizing Syndromes This test is indicated for women who exhibit virilizing symptoms, which may include the development of male characteristics such as hirsutism, voice deepening, and other signs of elevated androgen levels.
  • Suspected Anabolic Steroid Abuse The test is also performed when there is a suspicion of anabolic steroid abuse, as elevated androstenedione levels can be indicative of the use of anabolic agents that enhance athletic performance.

2. Procedure

The procedure for measuring androstenedione levels involves several key steps that ensure the accurate collection and analysis of the blood sample. The following procedural steps are outlined:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to follow specific guidelines, such as fasting or avoiding certain medications that could affect hormone levels. It is essential to ensure that the patient is adequately prepared to obtain reliable results.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to collect the necessary volume of blood. The venipuncture is a separately reportable service and must be documented appropriately.
  • Step 3: Sample Handling After collection, the blood sample is handled according to laboratory protocols to prevent contamination or degradation. The sample is then processed for analysis.
  • Step 4: Laboratory Analysis The blood sample is analyzed using quantitative high performance liquid chromatography-tandem mass spectrometry. This advanced analytical technique allows for precise measurement of androstenedione levels in the sample, providing accurate results for clinical interpretation.

3. Post-Procedure

After the blood sample has been collected and sent for analysis, there are typically no specific post-procedure care requirements for the patient. However, patients may be advised to monitor the venipuncture site for any signs of complications, such as excessive bleeding or infection. Results from the androstenedione test are usually available within a specified timeframe, and healthcare providers will discuss the findings with the patient to determine any necessary follow-up actions or treatments based on the results.

Short Descr ASSAY OF ANDROSTENEDIONE
Medium Descr ANDROSTENEDIONE
Long Descr Androstenedione
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
Q4 Service for ordering/referring physician qualifies as a service exemption
QW Clia waived test
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Pre-1990 Added Code added.
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