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The CPT® Code 82726 refers to a laboratory test specifically designed to measure the levels of very long chain fatty acids (VLCFA) in the blood. VLCFA are a type of fat molecule characterized by their aliphatic tails, which are longer than 22 carbon atoms. These fatty acids play a crucial role in cellular metabolism, particularly in the production of energy. When fatty acids are ingested or when stored triglycerides are released from adipose tissue, they serve as a source of fuel for the mitochondria, the energy-producing organelles within cells. The process of energy production involves the breakdown of these fatty acids through a mechanism known as beta oxidation, which ultimately leads to the generation of adenosine triphosphate (ATP), the primary energy currency of the cell. However, due to their large size, VLCFA require initial processing by peroxisomes—specialized cellular organelles responsible for the breakdown of fatty acids—before they can be utilized for energy by the mitochondria. In certain genetic disorders, particularly those related to adrenoleukodystrophy, the function of peroxisomes is impaired, preventing the effective breakdown of VLCFA. This dysfunction results in an accumulation of VLCFA in the bloodstream, which can have significant health implications. The test involves obtaining a blood sample through a procedure known as venipuncture, which is reported separately. The plasma obtained from the blood sample is then analyzed for VLCFA and branched chain fatty acids using advanced techniques such as liquid chromatography-tandem mass spectrometry, ensuring precise measurement and analysis of these important biomolecules.
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The CPT® Code 82726 is indicated for use in the evaluation of conditions associated with the accumulation of very long chain fatty acids in the blood. This test is particularly relevant for diagnosing and monitoring certain genetic disorders, including:
The procedure for obtaining the CPT® Code 82726 involves several key steps to ensure accurate measurement of very long chain fatty acids in the blood. The process begins with the collection of a blood sample from the patient. This is performed through a technique known as venipuncture, where a needle is inserted into a vein, typically in the arm, to draw blood. It is essential that the blood sample is collected in a manner that prevents contamination and preserves the integrity of the plasma for subsequent analysis.
Following the procedure for CPT® Code 82726, there are several considerations for post-procedure care. Patients may experience minor discomfort or bruising at the venipuncture site, which typically resolves on its own. It is advisable for patients to apply pressure to the site and keep it clean to prevent any potential complications. The results of the VLCFA test are usually available within a specified timeframe, and healthcare providers will discuss the findings with the patient to determine any necessary follow-up actions or treatments based on the results. Additionally, it is important for patients to inform their healthcare provider of any symptoms or changes in their health status that may arise after the test.
| Short Descr | LONG CHAIN FATTY ACIDS | Medium Descr | VERY LONG CHAIN FATTY ACIDS | Long Descr | Very long chain fatty acids | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | GA | Waiver of liability statement issued as required by payer policy, individual case |
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| 2021-01-01 | Note | AMA Guideline removed. |
| 1999-01-01 | Added | First appearance in code book in 1999. |
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