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The CPT® Code 84085 refers to the measurement of 6-phosphogluconate dehydrogenase (6PGD) levels in a blood sample. This enzyme plays a critical role in the pentose phosphate pathway, which is essential for cellular metabolism, particularly in red blood cells (RBCs). The process involves the conversion of 6-phosphogluconate into ribulose 5-phosphate, a key step in generating NADPH and ribose-5-phosphate, which are vital for various biosynthetic processes and maintaining cellular health. A deficiency in 6PGD can result in significant metabolic disturbances, particularly under stress conditions, leading to episodic hemolytic anemia. This condition is characterized by the destruction of red blood cells, which can occur during periods of increased metabolic demand or oxidative stress. Therefore, measuring the levels of 6PGD is crucial for diagnosing potential enzyme deficiencies and understanding their implications in RBC metabolism and overall health.
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The measurement of 6-phosphogluconate dehydrogenase (6PGD) levels is indicated in the following scenarios:
The procedure for measuring 6-phosphogluconate dehydrogenase (6PGD) levels involves several key steps:
After the procedure, the patient may be advised to resume normal activities unless otherwise directed by their healthcare provider. The results of the 6PGD test will typically be reviewed in conjunction with the patient's clinical history and other laboratory findings to assess for any potential enzyme deficiencies. If a deficiency is identified, further evaluation and management may be necessary to address the underlying condition and prevent complications associated with hemolytic anemia.
| Short Descr | ASSAY OF RBC PG6D ENZYME | Medium Descr | PHOSPHOGLUCONATE 6-DEHYD RBC | Long Descr | Phosphogluconate, 6-, dehydrogenase, RBC | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
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| Pre-1990 | Added | Code added. |
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