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Official Description

Estriol

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82677 refers to a laboratory test specifically designed to measure the concentration of estriol, an estrogen hormone, in the blood. Estriol plays a significant role in pregnancy and is primarily produced by the placenta. This test is crucial for assessing the risk of certain fetal abnormalities, including Down syndrome. Typically, estriol levels are evaluated in conjunction with other markers such as alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and inhibin-A. Together, these tests form a comprehensive maternal serum panel that aids in screening for potential fetal developmental issues. The measurement of estriol can be conducted using either plasma or serum obtained from a blood sample, which is collected through a procedure known as venipuncture. The analytical method employed for measuring estriol levels is chemiluminescent immunoassay, a sensitive and specific technique that allows for accurate quantification of this hormone in the bloodstream.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The estriol test (CPT® Code 82677) is indicated for the following conditions:

  • Assessment of Fetal Abnormalities This test is performed to evaluate the risk of fetal abnormalities, particularly Down syndrome, during pregnancy.
  • Part of Maternal Serum Panel Estriol levels are typically measured alongside other markers such as alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and inhibin-A as part of a comprehensive maternal serum panel.

2. Procedure

The procedure for measuring estriol levels involves several key steps:

  • Step 1: Patient Preparation Prior to the test, the patient may be advised to follow specific instructions regarding fasting or medication adjustments, although such requirements are not universally applicable and should be confirmed with the healthcare provider.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to draw the necessary volume of blood for testing.
  • Step 3: Sample Handling The collected blood sample is then processed to separate plasma or serum, which is required for the estriol measurement. Proper handling and storage of the sample are crucial to ensure accurate test results.
  • Step 4: Laboratory Analysis The estriol concentration in the plasma or serum is measured using a chemiluminescent immunoassay. This method utilizes specific antibodies that react with estriol, allowing for precise quantification of the hormone in the sample.

3. Post-Procedure

After the venipuncture procedure, patients may experience minor discomfort or bruising at the site of blood draw, which typically resolves quickly. There are generally no specific post-procedure care instructions required for the estriol test. However, patients should be informed about the potential for slight soreness and advised to contact their healthcare provider if they experience any unusual symptoms. The results of the estriol test will be interpreted in conjunction with other markers from the maternal serum panel to provide a comprehensive assessment of fetal health.

Short Descr ASSAY OF ESTRIOL
Medium Descr ASSAY OF ESTRIOL
Long Descr Estriol
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GA Waiver of liability statement issued as required by payer policy, individual case
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
KX Requirements specified in the medical policy have been met
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
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