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Official Description

Malate dehydrogenase

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83775 refers to a laboratory test specifically designed to measure the levels of malate dehydrogenase (MDH) in a biological sample. Malate dehydrogenase is an important enzyme that plays a critical role in various metabolic processes, particularly in the citric acid cycle, which is essential for energy production in cells. This enzyme exists in several isoforms, each differing in its subcellular location and specific functions within the body. The primary action of MDH involves the reversible catalysis of malate to oxaloacetate, a reaction that also facilitates the reduction of NAD+ to NADH. This process occurs mainly in the mitochondria and cytosol, highlighting the enzyme's significance in cellular metabolism. Additionally, MDH is involved in gluconeogenesis, the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. The measurement of MDH levels is typically conducted using spectrophotometry, a method that quantifies the concentration of substances by measuring the intensity of light absorbed by the sample. This test can provide valuable insights into metabolic function and enzyme activity within the body.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The malate dehydrogenase (MDH) test, represented by CPT® Code 83775, is indicated for various clinical scenarios where the assessment of metabolic function is necessary. The following conditions may warrant the performance of this laboratory test:

  • Metabolic Disorders The test may be utilized to evaluate metabolic disorders that affect energy production and utilization within the body.
  • Assessment of Mitochondrial Function It can be indicated in cases where mitochondrial dysfunction is suspected, as MDH plays a crucial role in mitochondrial metabolism.
  • Evaluation of Gluconeogenesis The test may be performed to assess gluconeogenesis, particularly in patients with abnormal glucose metabolism or diabetes.

2. Procedure

The procedure for measuring malate dehydrogenase (MDH) involves several key steps to ensure accurate results. The following outlines the procedural steps:

  • Step 1: Sample Collection A biological sample, typically blood or serum, is collected from the patient. Proper collection techniques must be followed to avoid contamination and ensure the integrity of the sample.
  • Step 2: Sample Preparation The collected sample is then prepared for analysis. This may involve centrifugation to separate serum from cellular components, depending on the type of sample collected.
  • Step 3: Spectrophotometric Analysis The prepared sample is subjected to spectrophotometric analysis. This technique measures the absorbance of light at specific wavelengths, allowing for the quantification of MDH levels based on the enzyme's activity in the sample.
  • Step 4: Data Interpretation The results obtained from the spectrophotometric analysis are interpreted by laboratory professionals. The MDH levels are compared against established reference ranges to determine if they fall within normal limits or indicate a potential metabolic issue.

3. Post-Procedure

After the malate dehydrogenase test is completed, the patient may not require any specific post-procedure care, as the test is non-invasive and does not typically involve any risks. However, it is essential for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions based on the findings. If abnormal MDH levels are detected, further diagnostic testing or clinical evaluation may be warranted to investigate underlying metabolic conditions or disorders. Additionally, healthcare providers should ensure that patients understand the implications of the test results and any potential lifestyle or treatment modifications that may be recommended.

Short Descr ASSAY MALATE DEHYDROGENASE
Medium Descr ASSAY OF MALATE DEHYDROGENASE
Long Descr Malate dehydrogenase
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2013-01-01 Changed Description Changed
Pre-1990 Added Code added.
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