CPT® Code 83775

The CPT® Code 83775 refers to a laboratory test specifically designed to measure the levels of malate dehydrogenase (MDH) in a biological sample. Malate dehydrogenase is an important enzyme that plays a critical role in various metabolic processes, particularly in the citric acid cycle, which is essential for energy production in cells. This enzyme exists in several isoforms, each differing in its subcellular location and specific functions within the body. The primary action of MDH involves the reversible catalysis of malate to oxaloacetate, a reaction that also facilitates the reduction of NAD+ to NADH. This process occurs mainly in the mitochondria and cytosol, highlighting the enzyme's significance in cellular metabolism. Additionally, MDH is involved in gluconeogenesis, the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. The measurement of MDH levels is typically conducted using spectrophotometry, a method that quantifies the concentration of substances by measuring the intensity of light absorbed by the sample. This test can provide valuable insights into metabolic function and enzyme activity within the body.