© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 82163 refers to a laboratory test that measures the levels of angiotensin II in the blood. Angiotensin II is a peptide hormone that plays a critical role in the regulation of blood pressure and fluid balance within the body. It is produced from angiotensin I through the action of the angiotensin I-converting enzyme (ACE). This hormone primarily acts on the smooth muscle of blood vessels, causing vasoconstriction, which leads to an increase in blood pressure. Additionally, angiotensin II stimulates the secretion of aldosterone, a hormone that promotes sodium retention in the kidneys, further influencing blood volume and pressure. The test involves obtaining a blood sample, which is typically collected through a procedure known as venipuncture. This process is separately reportable, meaning it should be documented and billed independently. Once the blood sample is collected, the plasma is analyzed using an immunoassay technique, which is a laboratory method that uses antibodies to detect and quantify the presence of angiotensin II in the sample. This test is essential for evaluating conditions related to blood pressure regulation and fluid balance, providing valuable information for diagnosing and managing various cardiovascular and renal disorders.
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