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Official Description

Carbon dioxide (bicarbonate)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82374 refers to the measurement of carbon dioxide (bicarbonate) levels in a blood sample. This procedure involves taking a blood sample to assess the total carbon dioxide (CO2) concentration, which is crucial for evaluating a patient's acid-base balance. The total CO2 level is comprised of several components, including CO2 itself, bicarbonate (HCO3-), and carbonic acid (H2CO3), with bicarbonate being the predominant element. Bicarbonate serves as a negatively charged electrolyte that plays a vital role in maintaining the acid-base equilibrium and electrical neutrality within cells. It works in conjunction with other electrolytes such as potassium, sodium, and chloride to ensure proper physiological function. The kidneys are responsible for the excretion and reabsorption of bicarbonate, thus regulating its levels in the bloodstream. The measurement of total CO2 provides a rough estimate of the bicarbonate concentration, which is essential for diagnosing and monitoring various metabolic conditions. The CO2 levels are typically determined using enzymatic methodologies, which offer accurate and reliable results for clinical assessment.

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